[氯贝丁酯对雌性肥胖 Zucker 大鼠心肌甘油三酯蓄积的影响]

[Effect of clofibrate on myocardial triglyceride accumulation in female obese Zucker rats].

作者信息

Yang Bang-xiang, Li Yu, Liao Ren, Tian Qi

机构信息

Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.

出版信息

Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Nov;39(6):962-4.

PMID:19253836

Abstract

OBJECTIVE

To determine the effect of clofibrate on myocardial triglyceride accumulation in female obese Zucker rats and its role in lipotoxic heart disease.

METHODS

Twenty four female Zucker rats were divided into four groups: lean rats+vehicle, lean rats+clofibrate, obese rats + vehicle, obese rats+clofibrate. Daily intraperitoneal injection of clofibrate (300 mg/kg) or vehicle (olive oil, 1 mL/kg) was given to the rats for two weeks. Plasma glucose, insulin, free fatty acids, triglycerdies, cholesterol, and cardiac triglycerdies and fatty acids were measured.

RESULTS

Clofibrate normalized plasma free fatty acid and cholesterol and reduced plasma triglyceride and insulin in obese rats. However, clofibrate led to accumulation of heart TG and increased myocardial long-chain unsaturated and monounsaturated fatty acids in obese rats.

CONCLUSION

Clofibrate aggravates myocardial triglyceride accumulation in female obese Zucker rats. Further studies are needed for the use of clofibrate in treating cardiac lipid accumulation.

摘要

目的

确定氯贝丁酯对雌性肥胖 Zucker 大鼠心肌甘油三酯蓄积的影响及其在脂毒性心脏病中的作用。

方法

将 24 只雌性 Zucker 大鼠分为四组：瘦大鼠 + 赋形剂组、瘦大鼠 + 氯贝丁酯组、肥胖大鼠 + 赋形剂组、肥胖大鼠 + 氯贝丁酯组。每日给大鼠腹腔注射氯贝丁酯（300 mg/kg）或赋形剂（橄榄油，1 mL/kg），持续两周。测量血浆葡萄糖、胰岛素、游离脂肪酸、甘油三酯、胆固醇以及心脏甘油三酯和脂肪酸。