[Changes of plasma total homocysteine in type I diabetic patients its association with diabetic vascular complications].

OBJECTIVE

To identify the differences and contributing factors of plasma total homocysteine (tHcy) in people with type II diabetes mellitus (T2DM) and people who had normal glucose tolerance (NGT), and to explore the association between plasma tHcy and diabetic vascular complications.

METHODS

One hundred and thirty-five people (fifty-five in NGT group, eighty in T2DM group) were enrolled in this cross sectional study. The height, weight, waist circumference, hip circumference, and blood pressure of the participants were measured. The body mass index (BMI) and waist-hip ratio (WHR) were calculated. The fasting plasma tHcy, serum vitamin B12, and plasma folic acid were determined. Oral glucose tolerance test and insulin releasing test were performed to assess insulin secretion area under the curve (AUC) and insulin sensitivity (HOMA-IR). Lipid profiles were also assessed at the same time.

RESULTS

T2DM patients had significantly higher plasma tHcy [(21.09 +/- 10.99) micromol/L] than the people in the NGT group [(3.70 +/- 5.54) micromol/L, P=0.000). The stepwise multiple regression analysis showed that LnAUCGlu and WC were independent contributors to the increase of plasma tHcy (adjusting R2=0.378, P=0.000). The logistic regression analysis showed that tHcy (OR=1.109) and age (OR=1.146) were associated with diabetic macroangiopathy.

CONCLUSION

Plasma tHcy increase in patients with type II diabetes. Glucose and WC are important contributors to the increase of plasma tHcy in T2DM patients. The increase of plasma tHcy contributes to diabetic macroangiopathy.