Zhou Jing, Jiang Neng-gang, Kuang Ling-han, Liao Juan
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Nov;39(6):1000-3.
To search for the best combined indicators for diagnosing immune thrombocytopenic purpura (ITP).
Reticulated platelet (RP), thrombopoietin (TPO), platelet-associated immunoglobulins (PAIgG, by ELISA), mean platelet volume (MPV), platelet distribution width (PDW), platelet-large cell ratio(P-LCR) by flow cytometry), and automated blood cytometer were tested in three groups of people: patients with ITP (n=45), healthy people (n=45), and patients without ITP (n=42). Receiver operating characteristic (ROC) curve, LSD-t test, logistic regression, and correlation analysis were performed to identify the best indicators for diagnosing ITP.
The patients with ITP had higher levels of RP, MPV, PDW, P-LCR, and PAIgG than the healthy people and the patients without ITP (P<0.05). The patients without ITP had higher TPO than the healthy people and the patients with ITP (P<0.05). RP and PAIgG were sensitive indicators to ITP. PR was correlated to the diagnosis of ITP (chi2=10.458, P=0.001).
Individual indicator has limited diagnostic values for ITP, which could be improved by a combination of the indicators.
寻找诊断免疫性血小板减少性紫癜（ITP）的最佳联合指标。
对三组人群进行检测，包括ITP患者（n = 45）、健康人（n = 45）和非ITP患者（n = 42），检测项目包括网织血小板（RP）、血小板生成素（TPO）、血小板相关免疫球蛋白（PAIgG，采用ELISA法）、平均血小板体积（MPV）、血小板分布宽度（PDW）、流式细胞仪检测的血小板大细胞比率（P-LCR）以及自动血细胞分析仪。采用受试者工作特征（ROC）曲线、LSD-t检验、逻辑回归和相关分析来确定诊断ITP的最佳指标。
ITP患者的RP、MPV、PDW、P-LCR和PAIgG水平高于健康人和非ITP患者（P < 0.05）。非ITP患者的TPO高于健康人和ITP患者（P < 0.05）。RP和PAIgG是ITP的敏感指标。PR与ITP的诊断相关（χ2 = 10.458，P = 0.001）。
单个指标对ITP的诊断价值有限，联合指标可提高诊断价值。
