[免疫性血小板减少性紫癜的联合诊断指标]

[Combined indicators for diagnosing immune thrombocytopenic purpura].

作者信息

Zhou Jing, Jiang Neng-gang, Kuang Ling-han, Liao Juan

机构信息

Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.

出版信息

Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Nov;39(6):1000-3.

PMID:19253846

Abstract

OBJECTIVE

To search for the best combined indicators for diagnosing immune thrombocytopenic purpura (ITP).

METHODS

Reticulated platelet (RP), thrombopoietin (TPO), platelet-associated immunoglobulins (PAIgG, by ELISA), mean platelet volume (MPV), platelet distribution width (PDW), platelet-large cell ratio(P-LCR) by flow cytometry), and automated blood cytometer were tested in three groups of people: patients with ITP (n=45), healthy people (n=45), and patients without ITP (n=42). Receiver operating characteristic (ROC) curve, LSD-t test, logistic regression, and correlation analysis were performed to identify the best indicators for diagnosing ITP.

RESULTS

The patients with ITP had higher levels of RP, MPV, PDW, P-LCR, and PAIgG than the healthy people and the patients without ITP (P<0.05). The patients without ITP had higher TPO than the healthy people and the patients with ITP (P<0.05). RP and PAIgG were sensitive indicators to ITP. PR was correlated to the diagnosis of ITP (chi2=10.458, P=0.001).

CONCLUSION

Individual indicator has limited diagnostic values for ITP, which could be improved by a combination of the indicators.

摘要

目的

寻找诊断免疫性血小板减少性紫癜（ITP）的最佳联合指标。

方法

对三组人群进行检测，包括ITP患者（n = 45）、健康人（n = 45）和非ITP患者（n = 42），检测项目包括网织血小板（RP）、血小板生成素（TPO）、血小板相关免疫球蛋白（PAIgG，采用ELISA法）、平均血小板体积（MPV）、血小板分布宽度（PDW）、流式细胞仪检测的血小板大细胞比率（P-LCR）以及自动血细胞分析仪。采用受试者工作特征（ROC）曲线、LSD-t检验、逻辑回归和相关分析来确定诊断ITP的最佳指标。