单核铜（II）酚盐仿生配合物具有催化多效性：可催化磷酸二酯键和肽酰胺键的断裂。
Mononuclear Cu(II)-phenolate bioinspired complex is catalytically promiscuous: phosphodiester and peptide amide bond cleavage.
作者信息
Oliveira Mauricio C Bof, Mazera Deise, Scarpellini Marciela, Severino Patricia Cardoso, Neves Ademir, Terenzi Hernán
机构信息
Centro de Biologia Molecular Estrutural, Departamento de Bioquímica, Universidade Federal de Santa Catarina, 88040-900 Florianópolis-SC, Brazil.
出版信息
Inorg Chem. 2009 Apr 6;48(7):2711-3. doi: 10.1021/ic802208v.
PMID:19254035
Abstract
In this work, the cleavage activity of the metal complex Cu(C(21)H(21)N(3)O(2))(OH(2))(2) is demonstrated to occur toward double-stranded DNA, in addition to its previously described amide bond cleavage activity, thus suggesting catalytic promiscuity for this complex.
摘要
在这项工作中，金属配合物[Cu(C₂₁H₂₁N₃O₂)(OH₂)₂]²⁺的切割活性被证明不仅对双链DNA有作用，此前还报道了其酰胺键切割活性，因此表明该配合物具有催化多效性。
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