Deleon Valerie Burke, Richtsmeier Joan T
John Hopkins University, Baltimore, MD, USA.
Cleft Palate Craniofac J. 2009 Mar;46(2):187-96. doi: 10.1597/08-001.1. Epub 2008 Jun 28.
To determine whether premature sagittal craniosynostosis is associated with developmental instability in the skull by analyzing fluctuating asymmetry in skull shape.
Cranial shape was quantified by collecting coordinate data from landmarks located on three-dimensional reconstructions of preoperative computed tomography (CT) images of 22 children with sagittal craniosynostosis and 22 age-matched controls. A fluctuating asymmetry application of Euclidean distance matrix analysis (EDMA) was used to quantify and compare asymmetry in cranial shape using these landmark data.
In contrast to expectations, the sagittal craniosynostosis group did not show a statistically significant increase in the overall level of fluctuating asymmetry relative to the control group. However, we discerned statistically significant localized increases in fluctuating asymmetry in the sagittal craniosynostosis group at pterion and the anterior clinoid processes (alpha = .05). We also determined a significant correlation of fluctuating asymmetry values between the two groups (r = .71).
We conclude that there is no evidence of a role for system-wide developmental instability in the etiology of nonsyndromic sagittal craniosynostosis. However, the localized evidence of asymmetry at the anterior clinoid processes in the sagittal synostosis group suggests an association with the tracts of dura mater that attach there.
通过分析颅骨形状的波动不对称性，确定早发性矢状缝早闭是否与颅骨发育不稳定有关。
通过收集22例矢状缝早闭患儿和22例年龄匹配的对照者术前计算机断层扫描（CT）图像三维重建上的标志点坐标数据，对颅骨形状进行量化。使用欧几里得距离矩阵分析（EDMA）的波动不对称应用，利用这些标志点数据量化和比较颅骨形状的不对称性。
与预期相反，矢状缝早闭组相对于对照组，波动不对称的总体水平没有统计学上的显著增加。然而，我们发现在翼点和前床突处，矢状缝早闭组的波动不对称有统计学上的显著局部增加（α = 0.05）。我们还确定了两组之间波动不对称值的显著相关性（r = 0.71）。
我们得出结论，没有证据表明全系统发育不稳定在非综合征性矢状缝早闭的病因中起作用。然而，矢状缝早闭组在前床突处不对称的局部证据表明与附着在那里的硬脑膜束有关。
