Ma Cui Qing, Li Cai Hong, Wang Xiu Rong, Zeng Rui Hong, Yin Xiao Lin, Feng Hui Dong, Wei Lin
Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang 050017, China.
Cell Mol Immunol. 2009 Feb;6(1):73-7. doi: 10.1038/cmi.2009.10.
Group A streptococcus (GAS), an important human pathogen, can cause various kinds of infections including superficial infections and potentially lethal infections, and the search for an effective vaccine to prevent GAS infections has been ongoing for many years. This paper compares the immunogenicity and immunoprotection of FbaA (an Fn-binding protein expressed on the surface of GAS) with that of M protein, the best immunogen of GAS. Assay for immune response showed that FbaA, similar to M protein, could induce protein-specific high IgG titer in BALB/c mice. Furthermore, following GAS challenge, the mice immunized with FbaA showed the same protective rate as those with M protein. These results indicate that FbaA is similar in ability to M protein in inducing protective immunity against GAS challenge in mice.
A组链球菌（GAS）是一种重要的人类病原体，可引起包括浅表感染和潜在致命感染在内的各种感染，多年来一直在寻找预防GAS感染的有效疫苗。本文比较了FbaA（一种在GAS表面表达的Fn结合蛋白）与GAS最佳免疫原M蛋白的免疫原性和免疫保护作用。免疫反应检测表明，FbaA与M蛋白相似，可在BALB/c小鼠中诱导蛋白特异性高IgG滴度。此外，在受到GAS攻击后，用FbaA免疫的小鼠显示出与用M蛋白免疫的小鼠相同的保护率。这些结果表明，FbaA在诱导小鼠针对GAS攻击的保护性免疫方面与M蛋白能力相似。
