雌性大鼠心肌梗死后死亡率的多普勒超声心动图预测指标

Doppler echocardiographic predictors of mortality in female rats after myocardial infarction.

作者信息

Santos Alexandra Alberta, Helber Izzo, Flumignan Ronald L G, Antonio Ednei L, Carvalho Antonio C, Paola Angelo A, Tucci Paulo J, Moises Valdir A

机构信息

Escola Paulista de Medicina-Universidade Federal de São Paulo, Disciplina de Cardiologia, São Paulo, Brazil.

出版信息

J Card Fail. 2009 Mar;15(2):163-8. doi: 10.1016/j.cardfail.2008.10.017. Epub 2008 Dec 25.

DOI:10.1016/j.cardfail.2008.10.017

PMID:19254677

Abstract

BACKGROUND

Doppler echocardiogram is useful for the evaluation of anatomical and functional changes in late myocardial infarction (MI) in rats. However, no studies have evaluated the prognostic value of echocardiographic parameters 1 week after MI.

METHODS AND RESULTS

Doppler echocardiogram was performed in 84 female Wistar rats 1 week after MI to determine infarction size, left chambers dimensions, fractional area change (FAC) of the left ventricle (LV), mitral inflow and tissue Doppler, myocardial performance index (MPI), and signs of pulmonary hypertension. The 365-day follow-up showed 53.6% mortality rate. Nonsurvivors showed larger (P < .05) MI size and cavity dimensions, poorer diastolic and systolic function, and higher frequency of pulmonary hypertension. Parameters at early stage of MI associated with higher mortality risk by Cox multivariate regression model were FAC <or=37% (relative risk [RR] 3.78, 95% CI, 1.50-9.53), MPI >or=0.60 (RR 3.49, 95% CI, 1.80-6.76), LV systolic area >or=0.26 cm(2) (RR 4.38, 95% CI, 1.88-10.21), E/E' ratio >or=20.3 (RR 2.12, 95% CI, 1.15-4.34), and E/A ratio associated with FAC (RR 2.99, 95% CI, 1.44-6.18).

CONCLUSION

Some diastolic and systolic Doppler echocardiographic parameters in rats may be able to predict late mortality risk after MI.

摘要

背景

多普勒超声心动图有助于评估大鼠晚期心肌梗死（MI）的解剖和功能变化。然而，尚无研究评估心肌梗死后1周超声心动图参数的预后价值。

方法与结果

对84只雌性Wistar大鼠在心肌梗死后1周进行多普勒超声心动图检查，以确定梗死面积、左心室腔尺寸、左心室（LV）的面积变化分数（FAC）、二尖瓣血流和组织多普勒、心肌性能指数（MPI）以及肺动脉高压体征。365天的随访显示死亡率为53.6%。非存活者表现出更大（P<0.05）的心肌梗死面积和腔尺寸、更差的舒张和收缩功能以及更高的肺动脉高压发生率。根据Cox多变量回归模型，与较高死亡风险相关的心肌梗死早期参数为FAC≤37%（相对风险[RR]3.78，95%CI，1.50 - 9.53）、MPI≥0.60（RR 3.49，95%CI，1.80 - 6.76）、左心室收缩面积≥0.26 cm²（RR 4.38，95%CI，1.88 - 10.21）、E/E'比值≥20.3（RR 2.12，95%CI，1.15 - 4.34）以及与FAC相关的E/A比值（RR 2.99，95%CI，1.44 - 6.18）。