朊病毒在细胞间穿行。
Prions tunnel between cells.
作者信息
Gerdes Hans-Hermann
机构信息
Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway.
出版信息
Nat Cell Biol. 2009 Mar;11(3):235-6. doi: 10.1038/ncb0309-235.
PMID:19255567
Abstract
Prions are abnormal isoforms of host proteins that are the infectious agents in certain mammalian neurodegenerative diseases. How prions travel from their peripheral entry sites to the brain where they cause disease is poorly understood. A new study finds that tunnelling nanotubes are important for the intercellular transfer of prions during neuroinvasion.
摘要
朊病毒是宿主蛋白的异常异构体，是某些哺乳动物神经退行性疾病的感染因子。朊病毒如何从其外周进入部位传播到引发疾病的大脑，目前尚不清楚。一项新研究发现，隧道纳米管在神经侵袭过程中对朊病毒的细胞间转移很重要。
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