当你衣冠不整时，脂肪有益而酸有害！
When you are Dishevelled, fat is good and acid is bad!
作者信息
Schweisguth François
机构信息
Institut Pasteur, CNRS URA2578, 25 rue du Dr Roux, 75015 Paris, France.
出版信息
Nat Cell Biol. 2009 Mar;11(3):237-9. doi: 10.1038/ncb0309-237.
PMID:19255568
Abstract
Frizzled receptors regulate cell fate decisions and planar cell polarity by means of distinct intracellular effectors. The choice between these two signalling outputs may involve a pH-dependent interaction between Dishevelled and negatively charged lipids at the plasma membrane.
摘要
卷曲受体通过不同的细胞内效应器调节细胞命运决定和平面细胞极性。这两种信号输出之间的选择可能涉及到细胞膜上Dishevelled与带负电荷脂质之间的pH依赖性相互作用。
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