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乳腺癌质量控制。

Breast cancer quality control.

作者信息

Patterson Cam, Ronnebaum Sarah

机构信息

Division of Cardiology and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, 8200 Medical Biomolecular Research Building, Chapel Hill, North Carolina 27599-7126, USA.

出版信息

Nat Cell Biol. 2009 Mar;11(3):239-41. doi: 10.1038/ncb0309-239.

DOI:10.1038/ncb0309-239
PMID:19255569
Abstract

Tumorigenesis is regulated by several mechanisms including signalling, transcription and DNA replication. Now a cytoplasmic protein quality-control pathway is implicated in the suppression of breast cancer cell growth, suggesting a new role for quality-control mechanisms in suppressing cells with malignant potential.

摘要

肿瘤发生受多种机制调控，包括信号传导、转录和DNA复制。现在，一种细胞质蛋白质质量控制途径与抑制乳腺癌细胞生长有关，这表明质量控制机制在抑制具有恶性潜能的细胞方面具有新作用。

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本文引用的文献

1
The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways.泛素连接酶CHIP作为致癌途径的上游调节因子。
Nat Cell Biol. 2009 Mar;11(3):312-9. doi: 10.1038/ncb1839. Epub 2009 Feb 8.
2
CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control.CHIP缺陷会缩短寿命，出现加速衰老的表型，同时蛋白质质量控制也会发生改变。
Mol Cell Biol. 2008 Jun;28(12):4018-25. doi: 10.1128/MCB.00296-08. Epub 2008 Apr 14.
3
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.
泛素化与泛素-蛋白酶体系统作为癌症上皮-间质转化中转录及转录因子的调节因子
Tumour Biol. 2012 Aug;33(4):897-910. doi: 10.1007/s13277-012-0355-x. Epub 2012 Mar 6.
热休克因子1是癌症发生的一种强大的多方面调节因子。
Cell. 2007 Sep 21;130(6):1005-18. doi: 10.1016/j.cell.2007.07.020.
4
SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock.类固醇受体共激活因子3（SRC-3）共激活因子的功能寿命由一个磷酸化依赖的泛素时钟调控。
Cell. 2007 Jun 15;129(6):1125-40. doi: 10.1016/j.cell.2007.04.039.
5
Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.泛素连接酶CHIP的缺失会导致内源性磷酸化和半胱天冬酶-3切割的tau蛋白种类的积累，但不会导致其聚集。
J Neurosci. 2006 Jun 28;26(26):6985-96. doi: 10.1523/JNEUROSCI.0746-06.2006.
6
Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.结蛋白相关心肌病中淀粉样蛋白诱导的心脏病的逆转
Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13592-7. doi: 10.1073/pnas.0503324102. Epub 2005 Sep 9.
7
CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation.CHIP通过泛素介导的降解调节Smad3的基础水平，从而控制转化生长因子-β信号传导的敏感性。
J Biol Chem. 2005 May 27;280(21):20842-50. doi: 10.1074/jbc.M412275200. Epub 2005 Mar 21.
8
Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor.雌激素受体泛素-蛋白酶体途径的配体依赖性转换
EMBO J. 2004 Dec 8;23(24):4813-23. doi: 10.1038/sj.emboj.7600472. Epub 2004 Nov 11.
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CHIP: a link between the chaperone and proteasome systems.CHIP：伴侣蛋白与蛋白酶体系统之间的联系。
Cell Stress Chaperones. 2003 Winter;8(4):303-8. doi: 10.1379/1466-1268(2003)008<0303:calbtc>2.0.co;2.
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CHIP activates HSF1 and confers protection against apoptosis and cellular stress.CHIP激活热休克因子1并赋予细胞抗凋亡和抗细胞应激的能力。
EMBO J. 2003 Oct 15;22(20):5446-58. doi: 10.1093/emboj/cdg529.