Patterson Cam, Ronnebaum Sarah
Division of Cardiology and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, 8200 Medical Biomolecular Research Building, Chapel Hill, North Carolina 27599-7126, USA.
Nat Cell Biol. 2009 Mar;11(3):239-41. doi: 10.1038/ncb0309-239.
Tumorigenesis is regulated by several mechanisms including signalling, transcription and DNA replication. Now a cytoplasmic protein quality-control pathway is implicated in the suppression of breast cancer cell growth, suggesting a new role for quality-control mechanisms in suppressing cells with malignant potential.
肿瘤发生受多种机制调控,包括信号传导、转录和DNA复制。现在,一种细胞质蛋白质质量控制途径与抑制乳腺癌细胞生长有关,这表明质量控制机制在抑制具有恶性潜能的细胞方面具有新作用。