Basak Surajit, Mukherjee Indranuj, Choudhury Mayukh, Das Santasabuj
Biomedical Informatics Center, National Institute of Cholera and Enteric Diseases, P-33, C.I.T Road, Scheme-XM, Beliaghata, Kolkata 700010, India.
Bioinformation. 2008;3(5):213-7. doi: 10.6026/97320630003213. Epub 2008 Dec 31.
Positive correlation between gene expression and synonymous codon usage bias is well documented in the literature. However, in the present study of Vibrio cholerae genome, we have identified a group of genes having unusually high codon usage bias despite being low potential expressivity. Our results suggest that codon usage in lowly expressed genes might also be selected on to preferably use non-optimal codons to maintain a low cellular concentration of the proteins that they encode. This would predict that lowly expressed genes are also biased in codon usage, but in a way that is opposite to the bias of highly expressed genes.
基因表达与同义密码子使用偏好之间的正相关在文献中有充分记载。然而，在目前对霍乱弧菌基因组的研究中，我们发现了一组基因，尽管其潜在表达能力较低，但密码子使用偏好却异常高。我们的结果表明，低表达基因的密码子使用也可能经过选择，优先使用非最优密码子，以维持其所编码蛋白质在细胞内的低浓度。这预示着低表达基因在密码子使用上也存在偏好，但方式与高表达基因的偏好相反。
