台湾人群中MD-1基因单核苷酸多态性与儿童及成人哮喘的关联。
Association of single nucleotide polymorphisms of MD-1 gene with pediatric and adult asthma in the Taiwanese population.
作者信息
Lee Shih-Wei, Wang Jiu-Yao, Hsieh Yuan-Chun, Wu Ying-Jye, Ting Hsien-Wei, Wu Lawrence Shih-Hsin
机构信息
Chest Medicine Department of Internal Medicine, Taoyuan General Hospital, Taoyuan, Taiwan.
出版信息
J Microbiol Immunol Infect. 2008 Dec;41(6):445-9.
BACKGROUND AND PURPOSE
MD-1 (myeloid differentiation 1; also known as Ly86, lymphocyte antigen 86), interacting with radioprotective 105, plays an important role in the Toll-like receptor 4 signaling pathway. It has been suggested that MD-1 is involved in the development of inflammation and atopic diseases. The purpose of this study was to investigate the genetic association of single nucleotide polymorphisms (SNPs) of MD-1 and asthma in the Taiwanese population.
METHODS
Genotyping 34 SNPs in the MD-1 gene region was performed in a case-control study involving 281 children with asthma and 237 controls. A further 309 children and adults were genotyped for the SNP rs7740529 only, for validation of an identified association.
RESULTS
In intron 1, we identified an SNP, rs7740529, which is associated with asthma in Taiwanese children (p=0.0358). Inclusion of a further 309 subjects increased the significance of the association (p=0.0093), and also demonstrated that rs7740529 is associated with adult asthma. The TT genotype confers risk of both pediatric and adult asthma.
CONCLUSION
These results suggest that MD-1 could be a susceptible gene for asthma in the Taiwanese population.
背景与目的
髓样分化蛋白1（MD-1；也称为Ly86，淋巴细胞抗原86）与辐射防护蛋白105相互作用，在Toll样受体4信号通路中发挥重要作用。有研究表明，MD-1参与炎症和特应性疾病的发生发展。本研究旨在探讨台湾人群中MD-1单核苷酸多态性（SNP）与哮喘的遗传关联。
方法
在一项病例对照研究中，对281例哮喘儿童和237例对照进行了MD-1基因区域34个SNP的基因分型。另外309名儿童和成人仅对SNP rs7740529进行基因分型，以验证已确定的关联。
结果
在内含子1中，我们鉴定出一个SNP，rs7740529，它与台湾儿童哮喘相关（p=0.0358）。纳入另外309名受试者增加了关联的显著性（p=0.0093），并且还表明rs7740529与成人哮喘相关。TT基因型赋予儿童和成人哮喘风险。
结论
这些结果表明，MD-1可能是台湾人群中哮喘的易感基因。
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