台湾人群中白细胞介素17A（IL17A）基因多态性及其与小儿哮喘的关联。
The polymorphisms of interleukin 17A (IL17A) gene and its association with pediatric asthma in Taiwanese population.
作者信息
Wang J Y, Shyur S D, Wang W H, Liou Y H, Lin C G J, Wu Y J, Wu L S H
机构信息
Department of Pediatrics, College of Medicine, National Cheng-Kung University, Tainan.
出版信息
Allergy. 2009 Jul;64(7):1056-60. doi: 10.1111/j.1398-9995.2009.01950.x. Epub 2009 Feb 5.
BACKGROUND
The interleukin 17A (IL17A) gene, located on chromosome 6p and linked to asthma phenotype, is a highly potential candidate gene conferring asthma susceptibility. The purpose of this study was to investigate the genetic association between single nucleotide polymorphisms (SNPs) of IL17A and asthma in Taiwanese children.
METHODS
We selected and performed genotyping on nine SNPs that encompass the genomic region of IL17A in Taiwanese children with or without asthma. A total of 1939 subjects containing 1027 subjects in testing group and 931 subjects in validation group were recruited in this study.
RESULTS
After Bonferroni correction, SNP rs8193036 was found to have a weak association (P = 0.0074 x 9 = 0.066) in genotype frequency test. This association was confirmed by validation group. Logistic regression adjusted allergy comorbidity and gender showed a slightly weaker association.
CONCLUSIONS
The results indicated an independent role of IL17A promoter polymorphism rs8193036 in the association with pediatric asthma in Taiwanese population.
背景
白细胞介素17A（IL17A）基因位于6号染色体短臂，与哮喘表型相关，是赋予哮喘易感性的极具潜力的候选基因。本研究旨在探讨台湾儿童中IL17A单核苷酸多态性（SNP）与哮喘之间的遗传关联。
方法
我们选择了涵盖台湾哮喘患儿和非哮喘患儿IL17A基因区域的9个SNP进行基因分型。本研究共招募了1939名受试者，其中测试组1027名，验证组931名。
结果
经Bonferroni校正后，SNP rs8193036在基因型频率测试中显示出弱关联（P = 0.0074×9 = 0.066）。该关联在验证组中得到证实。经逻辑回归调整过敏合并症和性别后，关联略显减弱。
结论
结果表明IL17A启动子多态性rs8193036在台湾人群小儿哮喘关联中具有独立作用。
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