DeClue Amy E, Schooley Elizabeth, Nafe Laura A, Reinero Carol R
Department of Medicine and Surgery, College of Veterinary Medicine, University of Missouri, 900 E. Campus Drive, Columbia, MO 65211, USA.
Inflamm Res. 2009 Aug;58(8):457-62. doi: 10.1007/s00011-009-0010-1. Epub 2009 Mar 3.
This study investigated if feG-COOH would decrease allergen-induced airway inflammation.
Seven adult cats sensitised to Bermuda grass allergen (BGA) to induce an asthmatic phenotype.
Cats were randomized to receive either feG-COOH (1 mg/kg, PO) or placebo (saline 1 ml, PO) immediately prior to BGA aerosol challenge in a cross-over design.
Bronchoalveolar lavage fluid (BALF) was collected and airway inflammatory response assessed via inflammatory cell number and type; IL-4, IFN-gamma and nitric oxide metabolite concentrations. A paired t test was used to compare parameters with a P < 0.05 considered significant.
The BALF eosinophil percentage was significantly lower in asthmatic cats treated with feG compared with placebo (placebo, 35.3 +/- 12.2%; feG, 22.4 +/- 8.6%; P = 0.002). Treatment with feG did not result in a significant change in any other parameter measured.
These data indicate that a single dose of feG-COOH partially attenuates eosinophilic airway inflammation in experimental feline asthma.
本研究调查了feG-COOH是否会减轻变应原诱导的气道炎症。
七只对百慕大草变应原（BGA）致敏以诱导哮喘表型的成年猫。
在交叉设计中，猫在接受BGA气雾剂激发前立即随机接受feG-COOH（1毫克/千克，口服）或安慰剂（1毫升生理盐水，口服）。
收集支气管肺泡灌洗液（BALF），并通过炎症细胞数量和类型、IL-4、IFN-γ和一氧化氮代谢物浓度评估气道炎症反应。采用配对t检验比较参数，P<0.05被认为具有显著性。
与安慰剂相比，接受feG治疗的哮喘猫的BALF嗜酸性粒细胞百分比显著降低（安慰剂，35.3±12.2%；feG，22.4±8.6%；P=0.002）。feG治疗并未导致所测量的任何其他参数发生显著变化。
这些数据表明，单剂量的feG-COOH可部分减轻实验性猫哮喘中的嗜酸性粒细胞气道炎症。
Zotero 插件