Abdul-Ghani Rashad, Loutfy Naguiba, el-Sahn Amel, Hassan Azza
Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.
Parasitol Res. 2009 Apr;104(5):955-65. doi: 10.1007/s00436-009-1371-7. Epub 2009 Mar 3.
Schistosomiasis still represents a major health problem in many tropical and subtropical countries despite continuing control efforts. Due to the unavailability of a vaccine that is practically applicable to humans, the use of chemotherapy is the mainstay of schistosomiasis-associated morbidity control. This paper attempts to review the antischistosomal drugs currently used in the treatment of intestinal schistosomiasis caused by Schistosoma mansoni. Their antischistosomal properties, advantages, and disadvantages as well as issues regarding the evidence for drug resistance and combination studies are reviewed in a simple manner. The recent trends towards the identification of specific chemotherapeutic targets for the treatment of schistosomes are also discussed briefly.
尽管一直在进行防治工作，但血吸虫病在许多热带和亚热带国家仍然是一个重大的健康问题。由于缺乏实际可应用于人类的疫苗，化疗仍是控制血吸虫病相关发病率的主要手段。本文试图综述目前用于治疗曼氏血吸虫引起的肠道血吸虫病的抗血吸虫药物。以简单的方式综述了它们的抗血吸虫特性、优缺点以及耐药性证据和联合研究等问题。还简要讨论了近期确定治疗血吸虫的特定化疗靶点的趋势。
