Department of Gastroenterology, Endoscopy Unit, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916 Badalona, Spain.
Dig Dis Sci. 2010 Feb;55(2):411-4. doi: 10.1007/s10620-009-0758-8. Epub 2009 Mar 3.
Capsule endoscopy (CE) has proven efficacy in detecting mucosal lesions of the upper gastrointestinal tract and it has been widely evaluated for assessing small-bowel lesions in patients with suspected or established Crohn's disease (CD).
To evaluate the impact of CE on the management of patients with established CD.
All patients with known CD that underwent CE were identified from IBD and endoscopy databases. Baseline characteristics of the study population, CE findings, changes in therapy, and patient outcome were recorded. Patients were followed for 18 months after CE.
CE was performed in 14 CD patients for iron deficiency anemia (n = 5) or abdominal pain of unknown origin (n = 3), or re-evaluation of disease location (n = 6). The overall diagnostic yield was 85.7%. As a result of the CE findings, CD therapy was changed in 64% of cases. Clinical outcome changed in three out of five patients with iron deficiency anemia and in two out of three patients with abdominal pain.
CE has a high diagnostic yield even in patients with previously known CD, and its findings may influence disease management and clinical outcome.
胶囊内镜 (CE) 已被证明可有效检测上消化道黏膜病变，并且已广泛评估其用于评估疑似或确诊克罗恩病 (CD) 患者的小肠病变。
评估 CE 对确诊 CD 患者治疗管理的影响。
从 IBD 和内镜数据库中确定所有接受 CE 的已知 CD 患者。记录研究人群的基线特征、CE 结果、治疗方案改变和患者结局。CE 后对患者进行 18 个月的随访。
CE 对 14 例 CD 患者进行了检查，其原因分别为缺铁性贫血（n = 5）或不明原因腹痛（n = 3），或重新评估疾病位置（n = 6）。总体诊断率为 85.7%。CE 结果改变了 64%的 CD 治疗方案。5 例缺铁性贫血患者中有 3 例和 3 例腹痛患者中有 2 例临床结局改变。
CE 即使在已知 CD 患者中也具有较高的诊断率，其发现可能影响疾病管理和临床结局。
