Baryshnikova L A, Aksenova V A, Fedorin I M
Probl Tuberk Bolezn Legk. 2009(1):30-3.
Examining 261 cases of active forms of tuberculosis in children and adolescents in the Samara Region in 1996 to 2004 indicated that 115 (44.1%) had earlier received chemoprophylaxis in the outpatient setting. The specific features of tuberculosis were revealed in this group of patients as compared with the children and adolescents who had never been treated with antituberculous drugs (n = 146): there was a predominance of preschool children; severe, disseminated forms of tuberculosis, detectable from complaints were observed less frequently; clinically cured pulmonary tuberculosis was more frequently characterized by residual posttuberculous changes. Outpatient chemoprophylaxis reduces the severity of the disease, but is not always effective in preventing tuberculosis.
对1996年至2004年萨马拉地区261例儿童和青少年活动性结核病病例的检查表明，115例（44.1%）此前在门诊接受过化学预防。与从未接受过抗结核药物治疗的儿童和青少年（n = 146）相比，该组患者的结核病呈现出以下特点：学龄前儿童占多数；严重的播散性结核病形式从主诉中检出的频率较低；临床治愈的肺结核更常伴有结核后残留改变。门诊化学预防可降低疾病的严重程度，但在预防结核病方面并不总是有效。
