Lebed'kov E V, Makarov D V, Sarmanaev S Kh
Klin Med (Mosk). 2009;87(1):63-5.
Overdose of cisplatin, a preparation with potentially high nephrotoxicity results in the damage of renal tubules, development of irreversible acute renal insufficiency, and death. Acute cisplatin poisoning requires maintenance and symptomatic treatment; antidotes are unknown. We report a case of successful therapy of acute cisplatin overdose in a 49 year-old patient by hemodialysis with successive inclusion of a column with hemosorbent before the dialyzer in the extracorporeal contour.
顺铂是一种具有潜在高肾毒性的制剂，过量使用会导致肾小管损伤、不可逆的急性肾功能不全以及死亡。急性顺铂中毒需要进行维持治疗和对症治疗；目前尚无解毒剂。我们报告了一例49岁急性顺铂过量患者通过血液透析成功治疗的病例，在体外循环中，透析器前连续接入装有血液吸附剂的柱体。
