Erickson Elizabeth S, Livanec Philip W, Frisz Jessica F, Dunn Robert C
Ralph N. Adams Institute for Bioanalytical Chemistry, Department of Chemistry, University of Kansas, Multidisciplinary Research Building, 2030 Becker Drive, Lawrence, Kansas 66047, USA.
Langmuir. 2009 May 5;25(9):5098-102. doi: 10.1021/la804104k.
Lipid monolayers of L-alpha-dipalmitoylphosphatidylcholine (DPPC) are used to pattern substrates using the Langmuir-Blodgett (LB) technique. Lipid monolayers are deposited onto freshly cleaved mica surfaces or glass capillaries under conditions that lead to distinct patterns in the film. Exposure of the supported monolayer to ethyl 2-cyanoacrylate fumes leads to preferential polymerization in the more hydrated regions of the patterned monolayer. This method enables surfaces to be micropatterned where the lateral features are controlled by the structure present in the underlying LB film, and the vertical feature size is controlled by the length of the fuming process. Atomic force microscopy (AFM) measurements confirm that the original structure in the LB film is preserved following fuming and that the lateral and vertical feature sizes can be controlled from nanometers to micrometers. This method, therefore, provides a rapid and versatile approach for micropatterning both flat and curved surfaces on a variety of substrates.
L-α-二棕榈酰磷脂酰胆碱（DPPC）的脂质单层通过朗缪尔-布洛杰特（LB）技术用于对基底进行图案化处理。脂质单层在导致薄膜中形成独特图案的条件下沉积到刚劈开的云母表面或玻璃毛细管上。将负载的单层暴露于氰基丙烯酸乙酯烟雾中会导致图案化单层中水分含量较高的区域优先发生聚合反应。这种方法能够对表面进行微图案化处理，其中横向特征由底层LB膜中的结构控制，垂直特征尺寸由熏蒸过程的时长控制。原子力显微镜（AFM）测量结果证实，熏蒸后LB膜中的原始结构得以保留，并且横向和垂直特征尺寸可以从纳米控制到微米。因此，这种方法为在各种基底上对平面和曲面进行微图案化处理提供了一种快速且通用的方法。
