Berkhout Ben
Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection & Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, The Netherlands.
Future Microbiol. 2009 Mar;4(2):151-4. doi: 10.2217/17460913.4.2.151.
Evaluation of: Leonard JN, Shah PS, Burnett JC, Schaffer DV: HIV evades RNA interference directed at TAR by an indirect compensatory mechanism. Cell Host Microbe 4, 484-494 (2008). RNAi can be used to induce the silencing of messenger RNAs in a sequence-specific manner. Several therapeutic RNAi applications are actively being pursued, including the targeting of the RNA genome of human pathogenic viruses such as HIV-1. Viruses are able to escape from RNAi attack by mutation of the targeted sequence. In this report, Leonard and co-workers present evidence of a more indirect viral escape route by selection of up-mutations in the promoter that boosts viral gene expression. This indirect route may serve as a general viral evasion mechanism.
伦纳德·JN、沙阿·PS、伯内特·JC、沙弗·DV：《HIV通过间接补偿机制逃避针对TAR的RNA干扰》。《细胞宿主与微生物》第4卷，第484 - 494页（2008年）。RNA干扰可用于以序列特异性方式诱导信使RNA沉默。目前正在积极探索几种治疗性RNA干扰应用，包括针对人类致病病毒如HIV - 1的RNA基因组。病毒能够通过靶向序列的突变逃避RNA干扰攻击。在本报告中，伦纳德及其同事通过选择启动子中的上调突变来提高病毒基因表达，提出了一种更间接的病毒逃逸途径的证据。这种间接途径可能是一种普遍的病毒逃避机制。
