Qiao Shu-Dong, Liu Na, Fan Dong-Sheng, Gao Xiao-Hong, Zhou Jian-Wen
Department of Neurology, Third Hospital of Peking University, Beijing 100083, China.
Zhonghua Yi Xue Za Zhi. 2008 Dec 23;88(47):3342-4.
To study the relationship between smoking and hyperhomocysteinemia (HHe) in ischemic stroke patients.
The clinical data of 329 ischemic stroke patients with HHe and 306 age-matched ischemic stroke patients without HHe, including sex, symptoms, signs, history of smoking, and plasma homocysteine (Hcy), folate, and vitamin B(12) concentrations were compared. The ischemic stroke lesions were divided into 2 subtypes: large vessel disease group and small vessel disease group according to the TOAST system.
The number of cigarettes smoked per day, cumulative year of smoking, and smoking index (number of cigarettes smoked per day X cumulative year of smoking), and ratio of males of the HHe group were all significantly higher than those of the non-HHe group, and the plasma homocysteine, folate, and vitamin B(12) concentrations of the HHe group were all significantly lower than those of the non-HHe group (all P < 0.01). Smoking index was positively correlated with the Hcy concentrations and negatively correlated with the folate and vitamin B(12) concentrations (all P < 0.01). The smoking proportion and Hcy concentration of the male patients were significantly higher than those of the female patients (both P < 0.01), and the plasma folate and vitamin B(12) concentrations of the male patients were all significantly lower than those of the female patients (P < 0.01 and P < 0.05). The number of cigarettes smoked per day, cumulative year of smoking, smoking index, and Hcy concentration of the large vessel disease group were all significantly higher than those of the small vessel disease group (all P < 0.01).
Smoking and being male may be the risk factors of HHe in ischemic stroke patients. Smoking and HHe are prone to cause lesion in large vessel.
研究缺血性脑卒中患者吸烟与高同型半胱氨酸血症（HHe）之间的关系。
比较329例伴有HHe的缺血性脑卒中患者和306例年龄匹配的不伴有HHe的缺血性脑卒中患者的临床资料，包括性别、症状、体征、吸烟史以及血浆同型半胱氨酸（Hcy）、叶酸和维生素B12浓度。根据TOAST系统将缺血性脑卒中病变分为2个亚型：大血管疾病组和小血管疾病组。
HHe组的每日吸烟量、吸烟累积年数、吸烟指数（每日吸烟量×吸烟累积年数）以及男性比例均显著高于非HHe组，且HHe组的血浆同型半胱氨酸、叶酸和维生素B12浓度均显著低于非HHe组（均P<0.01）。吸烟指数与Hcy浓度呈正相关，与叶酸和维生素B12浓度呈负相关（均P<0.01）。男性患者的吸烟比例和Hcy浓度显著高于女性患者（均P<0.01），且男性患者的血浆叶酸和维生素B12浓度均显著低于女性患者（P<0.01和P<0.05）。大血管疾病组的每日吸烟量、吸烟累积年数、吸烟指数和Hcy浓度均显著高于小血管疾病组（均P<0.01）。
吸烟和男性可能是缺血性脑卒中患者发生HHe的危险因素。吸烟和HHe易导致大血管病变。
