Comet B, Cutuli B, Penault-Llorca F, Bonneterre J, Belkacémi Y
CRLC Oscar-Lambret, université de Lille-II, Lille, France.
Bull Cancer. 2009 Feb;96(2):181-9. doi: 10.1684/bdc.2008.0813.
Male breast cancer (MBC) is considered as a rare disease comprising about 1% of all breast cancers. As compared to women breast cancer, MBC has some similarities and also some particularities related to age, comorbidities, breast volume, diagnostic delay, prognosis and survival. Modified radical mastectomy (MRM) with axillary dissection is the gold standard. Sentinel lymph node dissection is a promising option for early stages. Adjuvant radiation is proposed because of the high frequency of node involvement and central tumor location. In hormone receptor positive tumors tamoxifen remains the gold standard endocrine therapy because of the lack of data on aromatase inhibitors. Adjuvant chemotherapy can be proposed to high-risk patients while trastuzumab should be an option in breast cancer that overexpresses HER2. In the setting of considerable evolution in the management of women breast cancer, this review aimed to point out on the similarities and particularities of MBC and the future challenges to improve MBC outcome.
男性乳腺癌(MBC)被认为是一种罕见疾病,约占所有乳腺癌的1%。与女性乳腺癌相比,MBC在年龄、合并症、乳房体积、诊断延迟、预后和生存方面有一些相似之处,也有一些特殊性。改良根治性乳房切除术(MRM)加腋窝清扫是金标准。前哨淋巴结清扫是早期阶段的一个有前景的选择。由于淋巴结受累频率高和肿瘤位于中央,建议进行辅助放疗。在激素受体阳性肿瘤中,由于缺乏关于芳香化酶抑制剂的数据,他莫昔芬仍然是金标准内分泌治疗。辅助化疗可用于高危患者,而曲妥珠单抗应作为HER2过表达乳腺癌的一种选择。在女性乳腺癌管理有相当大进展的背景下,本综述旨在指出MBC的异同以及改善MBC治疗结果的未来挑战。