Yasuno Yoshiaki, Yamanari Masahiro, Kawana Keisuke, Oshika Testuro, Miura Masahiro
Computational Optics Group in the University of Tsukuba, Tsukuba, Ibaraki, Japan.
Opt Express. 2009 Mar 2;17(5):3980-96. doi: 10.1364/oe.17.003980.
A sequential case series of post-glaucoma-surgery structures examined by three-dimensional corneal and anterior eye segment optical coherence tomography (3D-CASOCT) and 3D polarization sensitive CASOCT (PS-CASOCT) is presented. A total of 5 patients who underwent glaucoma surgery were included in this study. Of these, 1, 1, and 3 patient underwent trabeculotomy, laser iridotomy, and trabeculectomy respectively. One patient each who had undergone trabeculotomy or laser iridotomy was examined using a prototype 3D-CASOCT. This prototype is based on swept-source OCT technology, uses a probe beam with a center wavelength of 1.31 microm, and has an axial resolution of 11.6 microm and a scanning speed of 20,000 A lines/s. All 3 patients who underwent trabeculectomy were examined by PS-CASOCT, which has similar specifications to those of 3DCASOCT, measures the depth-resolved birefringence of a specimen, and yields conventional OCT images. Detailed 3D visualization of the incision site of trabeculotomy and the ablation site of laser iridotomy was achieved using 3D-CASOCT. PS-CASOCT revealed, in addition to the structural details, the birefringent properties of the tissues of the trabeculectomy bleb. Some blebs showed abnormal birefringence in the conjunctiva and in a remnant fluid pool. This may indicate the existence of fibrosis in these regions. Both 3D-CASOCT and PS-CASOCT provide clinically significant information for the postoperative assessment of structures created during glaucoma surgery. Interactive 3D datasets of all cases are provided for interactive clinical review. Complex raw 3D OCT volumes are also provided as a reference dataset for the development of PS-OCT algorithms.
本文介绍了一系列通过三维角膜和眼前节光学相干断层扫描（3D - CASOCT）及三维偏振敏感CASOCT（PS - CASOCT）检查的青光眼手术后结构。本研究共纳入5例接受青光眼手术的患者。其中，分别有1例、1例和3例患者接受了小梁切开术、激光虹膜切开术和小梁切除术。接受小梁切开术或激光虹膜切开术的各1例患者使用原型3D - CASOCT进行检查。该原型基于扫频源OCT技术，使用中心波长为1.31微米的探测光束，轴向分辨率为11.6微米，扫描速度为20,000 A线/秒。所有3例接受小梁切除术的患者均通过PS - CASOCT进行检查，其规格与3D - CASOCT相似，可测量标本的深度分辨双折射，并生成传统的OCT图像。使用3D - CASOCT实现了小梁切开术切口部位和激光虹膜切开术消融部位的详细三维可视化。PS - CASOCT除了显示结构细节外，还揭示了小梁切除术后滤过泡组织的双折射特性。一些滤过泡在结膜和残余液池中显示出异常双折射。这可能表明这些区域存在纤维化。3D - CASOCT和PS - CASOCT都为青光眼手术中创建的结构的术后评估提供了具有临床意义的信息。提供了所有病例的交互式3D数据集用于交互式临床审查。还提供了复杂的原始3D OCT体积作为PS - OCT算法开发的参考数据集。
