Hellmeyer L, Iwinska-Zelder J, Gerken L, Kühnert M, Schmidt S
Kinik für Geburtshilfe und Perinatalmedizin, Philipps-Universität Marburg.
Z Geburtshilfe Neonatol. 2009 Feb;213(1):27-31. doi: 10.1055/s-0028-1119398. Epub 2009 Mar 3.
Pre-eclampsia affects 2% of pregnancies. This multisystem disorder is a major cause of maternal, foetal and neonatal mortality and morbidity. Neurological manifestations of eclampsia are headache, nausea, vomiting, cortical blindness and recurrent seizures.
The purpose of this study was to determine whether the neurological symptoms correlate with MR imaging findings.
In a patient with eclamptic seizure and another one with blindness due to pre-eclampsia, the white matter hyperintensities on T (2)-weighted MR and FLAIRsequence images could be demonstrated in the occipital region and in the basal ganglia. Within 3-5 days all neurological symptoms and radiological abnormalities had resolved.
These cerebral lesions could be classified as posterior reversible encephalopathy syndrome (PRES) or as reversible leukoencephalopathy syndrome (PLES). Thus, MRI supports differential diagnosis regarding non pregnancy-related cerebral disease and can be helpful for therapy planning in cases of pre-eclampsia.
子痫前期影响2%的妊娠。这种多系统疾病是孕产妇、胎儿和新生儿死亡及发病的主要原因。子痫的神经学表现为头痛、恶心、呕吐、皮质盲和反复癫痫发作。
本研究的目的是确定神经症状是否与磁共振成像（MR）结果相关。
在1例子痫性癫痫患者和另1例因子痫前期导致失明的患者中，在T（2）加权MR和液体衰减反转恢复（FLAIR）序列图像上，枕叶和基底节区可见白质高信号。在3 - 5天内，所有神经症状和放射学异常均消失。
这些脑部病变可归类为后部可逆性脑病综合征（PRES）或可逆性白质脑病综合征（PLES）。因此，MRI有助于鉴别与非妊娠相关的脑部疾病，并有助于子痫前期病例的治疗规划。
