Takemura Nobuyuki, Kokudo Norihiro, Imamura Hiroshi, Takazawa Yutaka, Sano Keiji, Sugawara Yasuhiko, Nakagawa Keiichi, Ohtomo Kuni, Makuuchi Masatoshi
Department of Surgery, Hepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Graduate School of Medicine, University of Tokyo, Japan.
Hepatogastroenterology. 2008 Nov-Dec;55(88):1997-9.
We report a 49-year-old man with unresectable intrahepatic cholangiocarcinoma (ICC) who was treated with oral tegafur-uracil (UFT) chemotherapy and survived for over a decade. In 1995, the patient was admitted to our institution after a large tumor in his left liver was detected using computed tomography (CT). The tumor was diagnosed as ICC, and a laparotomy was performed; however, the tumor was too advanced to perform a curative resection. The cancer had spread to the lymph nodes in the hepatoduodenal ligament and on the posterior surface of the pancreas head. A curative resection was abandoned, and oral UFT chemotherapy was started immediately after the laparotomy. The tumor remained almost unchanged until 2001 with only UFT administration; however, its size gradually increased to 7.8 cm in diameter. External-beam radiotherapy (50.4 Gy) was performed, and the tumor's size decreased to 6.3 cm in diameter. Eleven years have now passed since the laparotomy, and the patient continues to lead a normal daily life working as a banker. The cumulative dose of UFT has reached 2511 g without any significant adverse effects. This case suggests that oral UFT might suppress the progression of ICC, contributing to this patient's 11-year survival period.
我们报告了一名49岁的不可切除肝内胆管癌（ICC）男性患者，其接受口服替加氟-尿嘧啶（UFT）化疗并存活了十多年。1995年，该患者在通过计算机断层扫描（CT）检测到左肝有一个大肿瘤后入住我院。肿瘤被诊断为ICC，并进行了剖腹手术；然而，肿瘤进展过于严重，无法进行根治性切除。癌症已扩散至肝十二指肠韧带和胰头后表面的淋巴结。放弃了根治性切除，剖腹手术后立即开始口服UFT化疗。在仅给予UFT治疗期间，肿瘤在2001年之前几乎没有变化；然而，其大小逐渐增加至直径7.8厘米。进行了外照射放疗（50.4 Gy），肿瘤大小降至直径6.3厘米。自剖腹手术以来现已过去11年，该患者继续作为一名银行家过着正常的日常生活。UFT的累积剂量已达2511克，且无任何明显不良反应。该病例表明口服UFT可能抑制ICC的进展，促成了该患者11年的生存期。
