Goncharov N P, Katsya G V, Chagina N A, Gooren L J
Endocrinology Research Center, Moscow, Russia.
Andrologia. 2009 Apr;41(2):76-83. doi: 10.1111/j.1439-0272.2008.00863.x.
The study assessed anthropometric and laboratory variables, in particular testosterone (T) in a group of obese men of <40 years. Of 60 men with a body mass index (BMI) of >27 kg m(-2), 34 met the criteria of the metabolic syndrome (MS). Twenty men <40 years (with a BMI <25 kg m(-2)) were studied for comparison. It was found that with increasing BMI, levels of serum leptin, triglycerides, insulin, the ratio high-density lipoprotein (HDL) cholesterol/low-density liporotein (LDL) cholesterol, the waist circumference (WC), the area of visceral fat and systolic/diastolic blood pressure were higher, whereas insulin sensitivity (HOMA) and serum T were lower. Obesity (BMI 27-30 kg m(-2)) was associated with a decline in plasma T, but not with a decline in plasma sex hormone-binding globulin (SHBG). The latter was the case in more severe obesity (>30 kg m(-2)) qualifying as MS. In patients with MS, 58% variability of T levels could be predicted by combination of independent factors - SHBG, ratio LDL/HDL, insulin and leptin. On the other hand, in men with MS, 80% variance of concentrations of SHBG were predicted by triglycerides, HDL, glucose, leptin and surface of visceral adipose tissue. It is concluded that plasma T is significantly correlated with a number of features of the MS and, therefore, plasma T could serve as a marker of the MS.
该研究评估了一组年龄小于40岁的肥胖男性的人体测量学和实验室变量，特别是睾酮（T）。在60名体重指数（BMI）>27 kg/m²的男性中，34名符合代谢综合征（MS）标准。研究了20名年龄小于40岁（BMI<25 kg/m²）的男性作为对照。结果发现，随着BMI增加，血清瘦素、甘油三酯、胰岛素、高密度脂蛋白（HDL）胆固醇/低密度脂蛋白（LDL）胆固醇比值、腰围（WC）、内脏脂肪面积和收缩压/舒张压升高，而胰岛素敏感性（HOMA）和血清T降低。肥胖（BMI 27 - 30 kg/m²）与血浆T下降有关，但与血浆性激素结合球蛋白（SHBG）下降无关。在符合MS的更严重肥胖（>30 kg/m²）中情况则相反。在MS患者中，T水平58%的变异性可通过SHBG、LDL/HDL比值、胰岛素和瘦素等独立因素的组合来预测。另一方面，在MS男性中，SHBG浓度80%的变异可由甘油三酯、HDL、葡萄糖、瘦素和内脏脂肪组织表面积预测。结论是血浆T与MS的许多特征显著相关，因此血浆T可作为MS的一个标志物。
