Couce Alejandro, Blázquez Jesús
Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Cantoblanco, Madrid, Spain.
FEMS Microbiol Rev. 2009 May;33(3):531-8. doi: 10.1111/j.1574-6976.2009.00165.x. Epub 2009 Feb 26.
In recent years, there has been accumulating evidence that antibiotics, besides their antimicrobial action, potentially have a number of undesired side effects that can, at least in some cases, promote genetic variability of bacteria. In addition to resistant variants, antibiotics have also been shown to select mutator clones, thus stimulating evolution towards further resistance. Furthermore, mutations, recombination and horizontal gene transfer have been reported to be somehow affected when bacteria are exposed to subinhibitory concentrations of certain antibiotics. These findings may have implications for the use of antibiotics, because they may have undesired side effects, such as enhancing antibiotic resistance evolution. Here we present data supporting (or not) this fearsome possibility and discuss whether this potential threat should be taken into consideration.
近年来，越来越多的证据表明，抗生素除了具有抗菌作用外，还可能有许多不良副作用，至少在某些情况下，这些副作用会促进细菌的遗传变异性。除了耐药变体，抗生素还被证明能选择突变克隆，从而刺激细菌向进一步耐药性进化。此外，据报道，当细菌暴露于某些抗生素的亚抑菌浓度时，突变、重组和水平基因转移会受到某种程度的影响。这些发现可能会对抗生素的使用产生影响，因为它们可能会产生不良副作用，比如增强抗生素耐药性的进化。在此，我们展示支持（或不支持）这种可怕可能性的数据，并讨论是否应该考虑这种潜在威胁。
