一个用于根据N-乙酰基转移酶-2（NAT2）基因型推断人类NAT2酶表型的网络服务器。
A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype.
作者信息
Kuznetsov Igor B, McDuffie Michael, Moslehi Roxana
机构信息
Gen*NY*Sis Center for Excellence in Cancer Genomics, Department of Epidemiology and Biostatistics, University at Albany, One Discovery Drive, Rensselaer, NY 12144, USA.
出版信息
Bioinformatics. 2009 May 1;25(9):1185-6. doi: 10.1093/bioinformatics/btp121. Epub 2009 Mar 4.
Abstract
UNLABELLED
N-acetyltransferase-2 (NAT2) is an important enzyme that catalyzes the acetylation of aromatic and heterocyclic amine carcinogens. Individuals in human populations are divided into three NAT2 acetylator phenotypes: slow, rapid and intermediate. NAT2PRED is a web server that implements a supervised pattern recognition method to infer NAT2 phenotype from SNPs found in NAT2 gene positions 282, 341, 481, 590, 803 and 857. The web server can be used for a fast determination of NAT2 phenotypes in genetic screens.
AVAILABILITY
Freely available at http://nat2pred.rit.albany.edu.
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
摘要
未标注
N - 乙酰基转移酶 - 2（NAT2）是一种重要的酶，可催化芳香族和杂环胺类致癌物的乙酰化反应。人群中的个体分为三种NAT2乙酰化酶表型：慢乙酰化型、快乙酰化型和中间型。NAT2PRED是一个网络服务器，它采用监督模式识别方法，根据在NAT2基因第282、341、481、590、803和857位发现的单核苷酸多态性（SNP）来推断NAT2表型。该网络服务器可用于在基因筛查中快速确定NAT2表型。
可用性
可在http://nat2pred.rit.albany.edu免费获取。
补充信息
补充数据可在《生物信息学》在线获取。
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