Natsume Atsushi, Yoshida Jun
Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan.
Cell Adh Migr. 2008 Jul-Sep;2(3):186-91. doi: 10.4161/cam.2.3.6278. Epub 2008 Jul 13.
The treatment of high-grade gliomas remains difficult despite recent advances in surgery, radiotherapy and chemotherapy. True advances may emerge from the increasing understanding in molecular biology and discovery of novel mechanisms for the delivery of tumoricidal agents. In an attempt to overcome this formidable neoplasm, molecular approaches using gene therapy have been investigated clinically since 1992. The clinical trials have mainly been classified into three approaches: suicide gene therapy, immune gene therapy and oncolytic viral therapy. In this article, we review these approaches, which have been studied in previous and ongoing clinical trials.
尽管在手术、放疗和化疗方面取得了最新进展，但高级别胶质瘤的治疗仍然困难。对分子生物学的深入理解以及新型肿瘤杀伤剂递送机制的发现可能会带来真正的进展。自1992年以来，为了攻克这种难治性肿瘤，利用基因治疗的分子方法已进入临床研究阶段。临床试验主要分为三种方法：自杀基因治疗、免疫基因治疗和溶瘤病毒治疗。在本文中，我们回顾了这些已在既往及正在进行的临床试验中得到研究的方法。
