Department of Pharmaceutical Services, University of Chicago Medical Center, Chicago, IL, USA.
Am J Ther. 2009 Sep-Oct;16(5):437-45. doi: 10.1097/MJT.0b013e31818637de.
Osteoporosis is a skeletal disease that currently affects more than 25 million men and women in the United States. This silent affliction presents asymptomatically as the compromised bone composition in the body goes unrealized and may ultimately lead to fractures. Without treatment or preventative measures, the risks of morbidity and mortality are increased. Complications arising from osteoporosis are often a result of disease-related fractures, which can lead to decreased efficiency of activities of daily life, disabling pain, loss of independent living, and, in some instances, death. Early diagnosis is crucial, and treatment or prevention is highly recommended for the most optimal outcome. Individualized therapy is necessary due to the multitude of therapeutic options. As the population of Americans older than 65 years is expected to double by the year 2050, osteoporosis prevention and treatment will be vital to effective patient care.
骨质疏松症是一种骨骼疾病,目前影响着美国超过 2500 万男性和女性。这种无声的疾病通常没有症状,因为身体中受损的骨成分没有被察觉,最终可能导致骨折。如果不治疗或采取预防措施,发病率和死亡率的风险会增加。骨质疏松症引起的并发症通常是由与疾病相关的骨折引起的,这可能导致日常生活活动效率降低、疼痛致残、丧失独立生活能力,在某些情况下甚至导致死亡。早期诊断至关重要,为了获得最佳效果,强烈建议进行治疗或预防。由于有多种治疗选择,因此需要个体化治疗。预计到 2050 年,美国 65 岁以上人口将增加一倍,因此骨质疏松症的预防和治疗对于有效的患者护理至关重要。