Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Kanagawa, Japan.
Scand Cardiovasc J. 2009;43(5):298-303. doi: 10.1080/14017430902785493.
This study sought to assess predictive values of coronary flow velocity and an index of shear stress throughout the vessel for angiographic restenosis after sirolimus-eluting stent implantation.
The study patients underwent successful implantation of a sirolimus-eluting stent for de novo lesions located in native coronary vessels and underwent follow-up angiography 6-9 months later. The TIMI frame count method and quantitative digital angiographic analysis were performed based on the post-stenting angiogram. Coronary flow velocity and Reynolds number, an index of shear stress, were measured.
Post-stenting digital angiograms from 267 patients were analyzed. We divided the study patients into two groups: a Restenosis group with 21 patients and a Non-Restenosis group with 246 patients. The Restenosis group indicated significantly lower coronary flow velocity (137.7+/-35.6 mm/sec versus 241.1+/-72.9 mm/sec, p = 0.0001) and lower Reynolds number (107.0+/-35.8 versus 199.2+/-67.1, p = 0.0001) than did the Non-Restenosis group.
Lowered coronary flow velocity and shear stress after sirolimus-eluting stenting may predict the risk of restenosis.
本研究旨在评估西罗莫司洗脱支架植入术后血管造影再狭窄的冠状动脉血流速度和剪切应力指数的预测价值。
研究患者成功植入西罗莫司洗脱支架治疗位于原生冠状动脉的新发病变，并在 6-9 个月后进行随访血管造影。基于支架置入后的血管造影进行 TIMI 帧数法和定量数字血管造影分析。测量冠状动脉血流速度和雷诺数（剪切应力指数）。
对 267 例患者的支架置入后数字血管造影进行了分析。我们将研究患者分为两组：再狭窄组 21 例和无再狭窄组 246 例。再狭窄组的冠状动脉血流速度（137.7+/-35.6mm/sec 与 241.1+/-72.9mm/sec，p=0.0001）和雷诺数（107.0+/-35.8 与 199.2+/-67.1，p=0.0001）均显著低于无再狭窄组。
西罗莫司洗脱支架置入术后冠状动脉血流速度和剪切应力降低可能预测再狭窄的风险。
