[小脑高级别星形细胞瘤中的弥漫性骨髓转移。病例报告]
[Diffuse bone marrow metastasis in cerebellar high-grade astrocytoma. A case report].
作者信息
Freitas M R P, de Muzio S D C, Pessoa R C C, Stávale J N, Borges L R R, Malheiros S M F
机构信息
Departamento de Oncología, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Brasil.
出版信息
Rev Neurol. 2009;48(5):242-4.
INTRODUCTION
Cerebellar high-grade astrocytoma is uncommon. Although more prone to present cerebrospinal fluid dissemination, the cerebellar location is not particularly related to the occurrence of extra-cranial metastases, which are also unusual in supratentorial malignant gliomas.
CASE REPORT
A 46 year-old man with cerebellar anaplastic astrocytoma who developed pancytopenia due to extensive bone marrow metastases.
CONCLUSION
Extraneural metastases of brain gliomas are rare and the spread to the bone marrow confers an extremely poor prognosis for these patients. The expected improvement in glioma patients' survival due to the combination of more efficient therapies may lead to an increased incidence of this uncommon presentation, justifying a more rigorous follow-up of systemic manifestations.
引言
小脑高级别星形细胞瘤并不常见。尽管更容易出现脑脊液播散，但小脑部位与颅外转移的发生并无特别关联，而颅外转移在幕上恶性胶质瘤中也不常见。
病例报告
一名46岁患有小脑间变性星形细胞瘤的男性因广泛骨髓转移而出现全血细胞减少。
结论
脑胶质瘤的神经外转移罕见，骨髓转移会使这些患者的预后极差。由于更有效治疗方法的联合应用，预计胶质瘤患者生存率的提高可能会导致这种不常见表现的发生率增加，因此有必要对全身表现进行更严格的随访。
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