Foster Keith A
Syntaxin Ltd., Units 4-10, The Quadrant Barton Lane, Abingdon, Oxon, OX14 3YS, UK.
Toxicon. 2009 Oct;54(5):587-92. doi: 10.1016/j.toxicon.2009.01.037. Epub 2009 Mar 3.
Clostridial neurotoxins possess discrete structural domains with distinct pharmacological properties. Aspects of neurotoxin function with therapeutic potential include specific neuronal binding, intracellular (cytosolic) delivery of biologically active protein and inhibition of SNARE-mediated secretion. Understanding the structure function relationship of the neurotoxin protein enables the creation of recombinant proteins incorporating select domains of the neurotoxins to produce novel proteins with therapeutic potential in a range of clinical applications.
梭菌神经毒素具有具有不同药理学特性的离散结构域。具有治疗潜力的神经毒素功能方面包括特异性神经元结合、生物活性蛋白的细胞内（胞质）递送以及抑制SNARE介导的分泌。了解神经毒素蛋白的结构功能关系有助于创建包含神经毒素选定结构域的重组蛋白，以产生在一系列临床应用中具有治疗潜力的新型蛋白。
