Terry Janine, Lopez-Larson Melissa, Frazier Jean A
The Brain Institute, University of Utah, 383 Colorow Drive, Salt Lake City, UT 84108, USA.
Child Adolesc Psychiatr Clin N Am. 2009 Apr;18(2):421-39, ix-x. doi: 10.1016/j.chc.2008.12.004.
Over the past 5-10 years, advances in neuroimaging methods and study designs have begun to appear in the literature of early-onset bipolar disorder (onset before 18 years of age). This article contains an updated review of the literature regarding neuroimaging in youths with bipolar disorder (BPD), highlighting important new study designs and techniques. Overall, structural, functional (fMRI) and magnetic resonance spectroscopy (MRS) report consistent abnormalities in regions of the frontal lobe and limbic structures. Functional MRI and MRS studies also frequently report striatal and thalamic abnormalities in early-onset BPD. Future neuroimaging studies in youths with BPD should include longitudinal studies incorporating multimodal neuroimaging techniques.
在过去5至10年中，神经影像学方法和研究设计的进展已开始出现在早发性双相情感障碍（发病年龄在18岁之前）的文献中。本文包含了关于双相情感障碍（BPD）青少年神经影像学的文献更新综述，重点介绍了重要的新研究设计和技术。总体而言，结构、功能（功能磁共振成像）和磁共振波谱（MRS）报告显示额叶和边缘结构区域存在一致的异常。功能磁共振成像和MRS研究也经常报告早发性双相情感障碍患者纹状体和丘脑的异常。未来针对双相情感障碍青少年的神经影像学研究应包括采用多模态神经影像学技术的纵向研究。
