Petrov S A, Fedorko N L, Semeriukova I A
Ukr Biokhim Zh (1978). 1991 May-Jun;63(3):109-13.
Penetration of thiamine and its metabolites through the liver mitochondria and blood cells of white rats has been studied. It is shown that the catabolic forms of thiamine, thiochrome and 4-methyl-5 oxyethylthiasole penetrate through the mitochondria membranes at a larger extent than thiamine and its phosphoric esters. An increase in concentration of thiamine and its metabolites in the incubation medium from 0.1 mM to 3.2 mM leads to intensification of this process. The larger permeability of thiochrome and 4-methyl-5 oxyethylthiasole through biological membranes permits explaining the principles of catabolic thiamine forms removal from the tissues and organism.
已对硫胺素及其代谢产物穿透白鼠肝脏线粒体和血细胞的情况进行了研究。结果表明，硫胺素的分解代谢形式硫色素和4-甲基-5-羟乙基噻唑穿透线粒体膜的程度比硫胺素及其磷酸酯更大。孵育培养基中硫胺素及其代谢产物的浓度从0.1 mM增加到3.2 mM会导致这一过程加剧。硫色素和4-甲基-5-羟乙基噻唑通过生物膜的较大通透性有助于解释从组织和生物体中清除硫胺素分解代谢形式的原理。
