[Properties of the membrane fractions of kidney microsomes from rats with hereditary hypertension induced by stress].

Phospholipid composition of microsomal fraction from a medullar layer of kidneys has been studied in rats of the Wistar and SSHR lines (the latter is a line of animals whose arterial tension rises after a stress). The phospholipid protein ratio for this fraction in the both lines is 0.4. Under the stress the mentioned parameter rises only in the SSHR rats. Phosphatidylcholine amounting to approximately 50% is a basic phospholipid in the microsomal fraction of rats of the both lines. Interlinear differences are associated with the amount of phosphatidyl serine and phosphatidyl ethanolamine: the level of these phospholipids in the Wistar rats is 14 and 8%, that in the SSHR ones--0 and 37%, respectively. After stressing rats of the both lines the phosphatidylcholine amount in the membrane falls to 30%. In this case the level of phosphoinositides and phosphatidyl serine grows in the Wistar rats, the level of phosphatidyl ethanolamine--in the SSHR rats. Microviscosity of microsomal membranes in the range of temperatures 12-38 degrees C is determined using pyrene, a fluorescent probe. Annular lipids in membranes of cells in Wistar rats are characterized by higher viscosity than those in SSHR rats. Stresses promote a decrease of microviscosity in annular lipids of Wistar rats. In hypertensive rats the response of membranes to stress is different in animals of different generations of breeding but introduction of androsole acetate to stressed rats makes microviscosity characteristics of the membranes similar to those of the Wistar rat membranes.