用于傅里叶变换离子回旋共振质谱法分析石油的微芯片大气压光电离

Microchip atmospheric pressure photoionization for analysis of petroleum by Fourier transform ion cyclotron resonance mass spectrometry.

作者信息

Haapala Markus, Purcell Jeremiah M, Saarela Ville, Franssila Sami, Rodgers Ryan P, Hendrickson Christopher L, Kotiaho Tapio, Marshall Alan G, Kostiainen Risto

机构信息

Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014 Helsinki, Finland.

出版信息

Anal Chem. 2009 Apr 1;81(7):2799-803. doi: 10.1021/ac802427m.

DOI:10.1021/ac802427m

PMID:19267484

Abstract

Atmospheric pressure photoionization (APPI) Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) has significantly contributed to the molecular speciation of petroleum. However, a typical APPI source operates at 50 microL/min flow rate and thus causes a considerable mass load to the mass spectrometer. The recently introduced microchip APPI (microAPPI) operates at much lower flow rates (0.05-10 microL/min) providing decreased mass load and therefore decreased contamination in analysis of petroleum by FT-ICR MS. In spite of the 25 times lower flow rate, the signal response with microAPPI was only 40% lower than with a conventional APPI source. It was also shown that microAPPI provides very efficient vaporization of higher molecular weight components in petroleum analysis.

摘要

大气压光电离（APPI）傅里叶变换离子回旋共振质谱（FT-ICR MS）对石油的分子形态分析做出了重大贡献。然而，典型的APPI源以50微升/分钟的流速运行，因此会给质谱仪带来相当大的质量负荷。最近推出的微芯片APPI（microAPPI）以低得多的流速（0.05 - 10微升/分钟）运行，减少了质量负荷，从而降低了FT-ICR MS分析石油时的污染。尽管流速降低了25倍，但microAPPI的信号响应仅比传统APPI源低40%。研究还表明，microAPPI在石油分析中能非常有效地使高分子量成分汽化。