Roman H, Loisel C, Puscasiu L, Sentilhes L, Marpeau L
CHU de Rouen, clinique gynécologique et obstétricale, 1, rue de Germont, 76031 Rouen, cedex, France.
J Gynecol Obstet Biol Reprod (Paris). 2008 Dec;37 Suppl 8:S405-17. doi: 10.1016/S0368-2315(08)74781-1.
The first line of treatment recommended for women with idiopathic menorrhagia is pharmaceutical agents, i.e. levonorgestrel intra-uterine device, tranexamic acid, estroprogestatif pills, oral progestin and non-sterodial anti-inflammatory drugs. The second line of treatment is surgical, using endometrial curettage for women who desire pregnancy in the future. On the other hand, in women who no longer intend to get pregnant either endometrial ablation or hysterectomy can be used. The menorrhagia associated with endometrial polyps is treated through the hysteroscopic polypectomy, which result can be improved by the use of the levonorgestrel intra-uterine device or the endometrial ablation. The menorrhagia related to submucosal myomas is managed by hysteroscopic myomectomy, either as a first line of treatment or following the failure of the pharmaceutical management. The first line of treatment of interstitial myomas is represented by the medical management, followed by laparoscopic or abdominal myomectomy for women who still want to be pregnant, and by myomectomy or uterine arteries embolization for women who no longer desire pregnancy. Hysterectomy is the most efficient treatment of menorrhagia due to interstitial myomas, and may be proposed either as a third line of treatment for the myomectomy and embolization failures or as a second line of treatment for women who do not wish to conserve their uterus. Finally, the treatment for women with clinically or radiologically suspected adenomyosis is medical, followed by hysterectomy for women who desire no pregnancy.
特发性月经过多女性的一线治疗推荐药物,即左炔诺孕酮宫内节育器、氨甲环酸、雌孕激素复合片、口服孕激素和非甾体抗炎药。二线治疗是手术治疗,对于未来有怀孕意愿的女性采用子宫内膜刮宫术。另一方面,对于不再打算怀孕的女性,可采用子宫内膜切除术或子宫切除术。与子宫内膜息肉相关的月经过多通过宫腔镜息肉切除术治疗,使用左炔诺孕酮宫内节育器或子宫内膜切除术可改善治疗效果。与黏膜下肌瘤相关的月经过多通过宫腔镜肌瘤切除术治疗,可作为一线治疗方法,也可在药物治疗失败后采用。肌壁间肌瘤的一线治疗是药物治疗,对于仍想怀孕的女性,随后进行腹腔镜或开腹肌瘤切除术;对于不再想怀孕的女性,则进行肌瘤切除术或子宫动脉栓塞术。子宫切除术是治疗肌壁间肌瘤所致月经过多最有效的方法,可作为肌瘤切除术和栓塞术失败后的三线治疗方法,也可作为不希望保留子宫的女性的二线治疗方法。最后,对于临床或影像学疑似子宫腺肌病的女性,治疗方法是药物治疗,对于不打算怀孕的女性随后进行子宫切除术。