巢蛋白mRNA的表达是甲状腺肿瘤中的一种分化标志物。

Expression of nestin mRNA is a differentiation marker in thyroid tumors.

作者信息

Yamada Hiroya, Takano Toru, Ito Yasuhiro, Matsuzuka Fumio, Miya Akihiro, Kobayashi Kaoru, Yoshida Hiroshi, Watanabe Mikio, Iwatani Yoshinori, Miyauchi Akira

机构信息

Department of Laboratory Medicine, Osaka University Medical School, 2-2 D2, Yamadaoka, Suita, Osaka 565-0871, Japan.

出版信息

Cancer Lett. 2009 Jul 18;280(1):61-4. doi: 10.1016/j.canlet.2009.02.006. Epub 2009 Mar 5.

DOI:10.1016/j.canlet.2009.02.006

PMID:19268442

Abstract

Nestin is a maker that identifies stem cells in some adult tissues, and its expression is believed to relate to malignancy in cancer cells. In this study, we measured the expression levels of nestin mRNA in various kinds of thyroid tumor by the real-time quantitative reverse transcription-polymerase chain reaction. Unexpectedly, nestin mRNA was detected in almost all differentiated thyroid tumors and normal thyroid tissues, whereas extremely decreased expression was observed in anaplastic carcinomas, which are the most malignant of the thyroid follicular cell-derived tumors. These results suggest that nestin mRNA is a differentiation marker, and its expression does not relate to malignant characteristics in thyroid tumors.

摘要

巢蛋白是一种可识别某些成人组织中干细胞的标志物，其表达被认为与癌细胞的恶性程度相关。在本研究中，我们通过实时定量逆转录-聚合酶链反应测量了各种甲状腺肿瘤中巢蛋白mRNA的表达水平。出乎意料的是，在几乎所有分化型甲状腺肿瘤和正常甲状腺组织中均检测到巢蛋白mRNA，而在间变性癌（甲状腺滤泡细胞源性肿瘤中恶性程度最高的肿瘤）中观察到其表达极度降低。这些结果表明，巢蛋白mRNA是一种分化标志物，其表达与甲状腺肿瘤的恶性特征无关。