Shanker Kanne, Rohini Rondla, Ravinder Vadde, Reddy P Muralidhar, Ho Yen-Peng
Department of Chemistry, Kakatiya University, Warangal, AP, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2009 Jul;73(1):205-11. doi: 10.1016/j.saa.2009.01.021. Epub 2009 Jan 31.
Reactions of [RuCl2(DMSO)4] with some of the biologically active macrocyclic Schiff base ligands containing N4 and N2O2 donor group yielded a number of stable complexes, effecting complete displacement of DMSO groups from the complex. The interaction of tetradentate ligand with [RuCl2(DMSO)4] gave neutral complexes of the type [RuCl2(L)] [where L=tetradentate macrocyclic ligand]. These complexes were characterized by elemental, IR, 1H, 13C NMR, mass, electronic, thermal, molar conductance and magnetic susceptibility measurements. An octahedral geometry has been proposed for all complexes. All the macrocycles and macrocyclic Ru(II) complexes along with existing antibacterial drugs were screened for antibacterial activity against Gram +ve (Bacillus subtilis, Staphylococcus aureus) and Gram -ve (Escherichia coli, Klebsiella pneumonia) bacteria. All these compounds were found to be more active when compared to streptomycin and ampicillin. The representative macrocyclic Schiff bases and their complexes were also tested in vitro to evaluate their activity against fungi, namely, Aspergillus flavus and Fusarium species.
[RuCl₂(DMSO)₄]与一些含有N₄和N₂O₂供体基团的生物活性大环席夫碱配体反应，生成了许多稳定的配合物，实现了二甲基亚砜基团从配合物中的完全取代。四齿配体与[RuCl₂(DMSO)₄]相互作用生成了[RuCl₂(L)]类型的中性配合物（其中L = 四齿大环配体）。这些配合物通过元素分析、红外光谱、¹H、¹³C核磁共振、质谱、电子光谱、热分析、摩尔电导率和磁化率测量进行了表征。已为所有配合物提出了八面体几何结构。对所有大环和大环Ru(II)配合物以及现有的抗菌药物进行了针对革兰氏阳性菌（枯草芽孢杆菌、金黄色葡萄球菌）和革兰氏阴性菌（大肠杆菌、肺炎克雷伯菌）的抗菌活性筛选。与链霉素和氨苄青霉素相比，所有这些化合物都表现出更高的活性。还对代表性的大环席夫碱及其配合物进行了体外测试，以评估它们对真菌，即黄曲霉和镰刀菌属的活性。
