利什曼原虫通过中性粒细胞控制宿主的炎症反应。
Leishmania commandeers the host inflammatory response through neutrophils.
作者信息
Jochim Ryan C, Teixeira Clarissa
机构信息
Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, 12735 Twinbrook Parkway, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
出版信息
Trends Parasitol. 2009 Apr;25(4):145-7. doi: 10.1016/j.pt.2009.01.001. Epub 2009 Mar 5.
Neutrophils are the first cells to migrate to the site of tissue damage. Recent work has addressed Leishmania survival and entry into macrophages through the infection of neutrophils that are recruited as a normal response to sandfly bites. New findings indicate that Leishmania is able to escape from neutrophils and 'silently' enter macrophages, a modification of the 'Trojan horse' model. Neutrophil depletion impaired disease progression, indicating an important role for neutrophils in leishmaniasis.
中性粒细胞是最早迁移至组织损伤部位的细胞。近期的研究探讨了利什曼原虫在被招募来正常应对白蛉叮咬的中性粒细胞感染后，在其中的存活及进入巨噬细胞的情况。新发现表明，利什曼原虫能够从中性粒细胞中逃脱并“悄然”进入巨噬细胞，这是对“特洛伊木马”模型的一种修正。中性粒细胞耗竭会损害疾病进展，这表明中性粒细胞在利什曼病中发挥着重要作用。
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