Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, USA.
Front Cell Infect Microbiol. 2012 May 4;2:59. doi: 10.3389/fcimb.2012.00059. eCollection 2012.
Neutrophils are the first cells recruited to the dermal site of Leishmania infection following injection by needle or sand fly bite. The role of neutrophils in either promoting or suppressing host immunity remains controversial. We discuss the events driving neutrophil recruitment, their interaction with the parasite and apoptotic fate, and the nature of their encounters with other innate cells. We suggest that the influence of the neutrophil response on infection outcome critically depends on the timing of their recruitment and the tissue environment in which it occurs.
中性粒细胞是通过针注射或沙蝇叮咬感染利什曼原虫后，首先被招募到皮肤部位的细胞。中性粒细胞在促进或抑制宿主免疫中的作用仍存在争议。我们讨论了驱动中性粒细胞募集的事件、它们与寄生虫的相互作用和凋亡命运，以及它们与其他先天细胞相遇的性质。我们认为，中性粒细胞反应对感染结果的影响取决于其募集的时间和发生的组织环境。
