Wang Angela Yee-Moon
University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, PR China.
Perit Dial Int. 2009 Feb;29 Suppl 2:S9-S14.
Cardiovascular disease is the leading cause of mortality in patients with end-stage renal disease (ESRD) and is attributed to a combination of traditional and non-traditional cardiovascular risk factors. In recent years, there has also been an increasing recognition of a very high prevalence of cardiovascular calcification in the ESRD population, including in patients receiving long-term peritoneal dialysis (PD). Numerous observational cohort studies have demonstrated the prognostic importance of cardiovascular calcifications in these patients. The mechanisms are not completely understood, but are likely multifactorial. The present article reviews the prevalence, clinical course, prognostic significance, and some contributing factors for vascular and valvular calcification in ESRD patients, including patients receiving PD therapy.
心血管疾病是终末期肾病（ESRD）患者死亡的主要原因，这归因于传统和非传统心血管危险因素的综合作用。近年来，人们也越来越认识到ESRD人群中，包括接受长期腹膜透析（PD）的患者，心血管钙化的患病率非常高。大量观察性队列研究已经证明了心血管钙化在这些患者中的预后重要性。其机制尚未完全了解，但可能是多因素的。本文综述了ESRD患者，包括接受PD治疗的患者，血管和瓣膜钙化的患病率、临床过程、预后意义以及一些促成因素。
