使用奥氮平口腔崩解片治疗期间体重减轻：两例病例报告。

Weight loss during therapy with olanzapine orally disintegrating tablets: two case reports.

作者信息

Kozumplik Oliver, Uzun Suzana, Jakovljević Miro

机构信息

University Department, Vrapce Psychiatric Hospital, Bolnicka cesta 32, 10090 Zagreb, Croatia.

出版信息

Psychiatr Danub. 2009 Mar;21(1):72-4.

PMID:19270625

Abstract

The aim of this article is to report weight loss in patients with schizophrenia after switching from olanzapine standard oral tablet (SOT) to olanzapine orally disintegrating tablets (ODT). In the first case report, the patient was switched to olanzapine ODT in daily dosage of 20 mg, while in the second case report, the patient was switched to olanzapine ODT in daily dosage of 15 mg, and weight loss was similar (14 kg vs. 15 kg). Switching patients from olanzapine SOT to olanzapine ODT treatment resulted in significant weight loss that was maintained during 12 months in both case reports. Further controlled clinical investigations are necessary to evaluate change in weight during treatment with olanzapine ODT, and to improve our understanding of this change.

摘要

本文旨在报告精神分裂症患者从奥氮平标准口服片剂（SOT）换用奥氮平口腔崩解片（ODT）后的体重减轻情况。在第一例病例报告中，患者换用每日剂量为20 mg的奥氮平ODT，而在第二例病例报告中，患者换用每日剂量为15 mg的奥氮平ODT，体重减轻情况相似（分别减轻14 kg和15 kg）。在两例病例报告中，患者从奥氮平SOT换用奥氮平ODT治疗均导致显著体重减轻，且在12个月内保持稳定。有必要进行进一步的对照临床研究，以评估使用奥氮平ODT治疗期间的体重变化，并增进我们对这一变化的理解。