Ceylan Berit G, Yilmaz Funda, Eroglu Fusun, Yavuz Lutfi, Gulmen Senol, Vural Huseyin
Department of Anesthesiology and Reanimation, University of Suleyman Demirel, Isparta, Turkey.
Saudi Med J. 2009 Mar;30(3):371-6.
To investigate the correlation between propofol and desflurane in terms of lipid peroxidation and antioxidant activity and to search the possible antioxidant anesthesia technique.
The study was performed in the Department of Anesthesia and Reanimation, Medical Faculty, Suleyman Demirel University, Isparta, Turkey, between January 2006 and July 2006. Thirty, ASA I-II patients, with an age range of 19-55 years, undergoing elective surgery under general anesthesia were randomized to receive either propofol infusion (Group P) or desflurane inhalation (Group D) following standard induction. Malondialdehyde (MDA), glutathione peroxidase (GSH), super oxide dismutase (SOD) and alpha-tocopherol (Vitamin E) were measured preoperatively, at peroperatively first hour and postoperatively 12-hour.
Malondialdehyde was found lower peroperatively in Group P compared to Group D (p<0.05). In Group D, Vitamin E levels were decreased significantly peroperatively compared to preoperative period (p=0.001).
We observed a systemic oxidative stress increment with desflurane by terms of MDA; a lipid peroxidation product and endogenous antioxidant activity suppression by terms of Vitamin E at only peroperative period. This study may be defined to support the fact that free oxygen radicals were released more by desflurane than propofol.
研究丙泊酚和地氟醚在脂质过氧化和抗氧化活性方面的相关性，并探寻可能的抗氧化麻醉技术。
本研究于2006年1月至2006年7月在土耳其伊斯帕尔塔市苏莱曼·德米雷尔大学医学院麻醉与复苏科进行。30例年龄在19 - 55岁之间、美国麻醉医师协会（ASA）分级为I - II级、接受全身麻醉下择期手术的患者，在标准诱导后随机分为丙泊酚输注组（P组）或地氟醚吸入组（D组）。在术前、术中第1小时和术后12小时测量丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH）、超氧化物歧化酶（SOD）和α - 生育酚（维生素E）。
与D组相比，P组术中丙二醛水平较低（p<0.05）。在D组中，术中维生素E水平与术前相比显著降低（p = 0.001）。
就丙二醛而言，我们观察到地氟醚会导致全身氧化应激增加；仅在术中，就维生素E而言，地氟醚会抑制脂质过氧化产物和内源性抗氧化活性。本研究可能支持地氟醚比丙泊酚释放更多游离氧自由基这一事实。
