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IVIG trials in MS. Is albumin a placebo?

作者信息

Hommes Otto R, Haas Judith, Soelberg-Sorenson Per, Friedrichs Mieke

出版信息

J Neurol. 2009 Feb;256(2):268-70. doi: 10.1007/s00415-009-0893-3. Epub 2009 Mar 1.

DOI:10.1007/s00415-009-0893-3

PMID:19271102

Abstract

摘要

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IVIG trials in MS. Is albumin a placebo?

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本文引用的文献

Intravenous immunoglobulin in relapsing-remitting multiple sclerosis: a dose-finding trial.

Neurology. 2008 Jul 22;71(4):265-71. doi: 10.1212/01.wnl.0000318281.98220.6f.

Intravenous immunoglobulin in primary and secondary chronic progressive multiple sclerosis: a randomized placebo controlled multicentre study.

Mult Scler. 2007 Nov;13(9):1107-17. doi: 10.1177/1352458507078400. Epub 2007 Jul 10.

A double-blind, randomized trial of IV immunoglobulin treatment in acute optic neuritis.

Neurology. 2005 Mar 8;64(5):804-10. doi: 10.1212/01.WNL.0000152873.82631.B3.

Albumin treatment reduces neurological deficit and protects blood-brain barrier integrity after acute intracortical hematoma in the rat.

Stroke. 2005 Feb;36(2):326-31. doi: 10.1161/01.STR.0000152949.31366.3d. Epub 2005 Jan 6.

IV immunoglobulins as add-on treatment to methylprednisolone for acute relapses in MS.

Neurology. 2004 Dec 14;63(11):2028-33. doi: 10.1212/01.wnl.0000145798.61383.39.

Intravenous immunoglobulin treatment following the first demyelinating event suggestive of multiple sclerosis: a randomized, double-blind, placebo-controlled trial.

Arch Neurol. 2004 Oct;61(10):1515-20. doi: 10.1001/archneur.61.10.1515.

Intravenous immunoglobulin in secondary progressive multiple sclerosis: randomised placebo-controlled trial.

Lancet. 2004;364(9440):1149-56. doi: 10.1016/S0140-6736(04)17101-8.

The role of qualitative and quantitative MRI assessment of multiple sclerosis lesions according to their in evaluating the efficacy of intravenous immunoglobulin G.

Neuroradiology. 2004 Apr;46(4):287-90. doi: 10.1007/s00234-003-1088-8. Epub 2004 Mar 4.

A randomized, double-blind, placebo-controlled pilot study of i.v. immune globulins in combination with i.v. methylprednisolone in the treatment of relapses in patients with MS.

Mult Scler. 2004 Feb;10(1):89-91. doi: 10.1191/1352458504ms978sr.

No difference in efficacy of two different doses of intravenous immunoglobulins in MS: clinical and MRI assessment.

Eur J Neurol. 2002 Nov;9(6):565-72. doi: 10.1046/j.1468-1331.2002.00500.x.

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