Lui Wing-Yee, Lee Will M
School of Biological Sciences, University of Hong Kong, Hong Kong, People's Republic of China.
J Mol Endocrinol. 2009 Aug;43(2):43-51. doi: 10.1677/JME-08-0174. Epub 2009 Mar 9.
Hormones and cytokines are known to regulate cellular functions in all tissues including testis. These two groups of biomolecules exert a broad spectrum of effects on various aspects of spermatogenesis. Among them, one of the regulatory effects on spermatogenesis is to modulate cell junction restructuring between Sertoli cells and between Sertoli and germ cells in the seminiferous epithelium. The restructuring of cell junctions is crucial to enable the migration of germ cells along the seminiferous epithelium from the basement membrane towards the tubular lumen, and at the same time for their attachment to Sertoli cells for support. This review will summarize the recent findings that focus on the role of hormones (FSH and testosterone) and cytokines (transforming growth factor-betas and tumor necrosis factor-alpha) on cell junction restructuring in the testis and the molecular mechanisms.
众所周知，激素和细胞因子可调节包括睾丸在内的所有组织中的细胞功能。这两类生物分子对精子发生的各个方面都具有广泛的影响。其中，对精子发生的一种调节作用是调节支持细胞之间以及支持细胞与生精上皮中生精细胞之间的细胞连接重组。细胞连接的重组对于使生精细胞沿着生精上皮从基底膜向管腔迁移至关重要，同时也有助于它们附着于支持细胞以获得支持。本综述将总结近期的研究发现，这些发现聚焦于激素（促卵泡激素和睾酮）和细胞因子（转化生长因子β和肿瘤坏死因子α）在睾丸细胞连接重组中的作用及其分子机制。
