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睾酮通过预防细胞粘附分子1（CADM1）缺陷减轻脊髓损伤对雄性生殖的影响。

Testosterone Reduces Spinal Cord Injury-Induced Effects on Male Reproduction by Preventing CADM1 Defect.

作者信息

Choobineh Hamid, Kazemi Mahsa, Sadighi Gilani Mohammad Ali, Heydari Tahereh, Shokri Saeed, Bazrafkan Mahshid, Hassanzadeh Gholamreza

机构信息

School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.

Zeoonosis Research Center, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Cell J. 2018 Jul;20(2):138-149. doi: 10.22074/cellj.2018.5003. Epub 2018 Mar 18.

DOI:10.22074/cellj.2018.5003
PMID:29633590
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5893284/
Abstract

OBJECTIVES

This study evaluated the effects of exogenous testosterone molecule-1 (CADM1) pathological defect during early and chronic periods of spinal cord injury (SCI).

MATERIALS AND METHODS

In this experimental study, Testosterone was administered immediately or after one week of SCI induction. Along with quantification of CADM1 gene expression and its immunoreactivity, we evaluated sperm parameters and serum testosterone level post-SCI.

RESULTS

Different grades of abnormalities in sperm parameters and testis architecture were observed along with significant reductions in the level of CADM1 expression and its immunoreactivity in the seminiferous tubules of both acute and chronic SCI groups. Exogenous testosterone, by compensating the serum testosterone level. reduced the percentage of apoptotic and both short head and abnormal sperm froms in the caudal epididymis. Importantly, the beneficial effects of immediate administration of testosterone were prominent. Increases in the level of CADM1 transcription and its immunoreactivity in the testis of SCI mice treated with testosterone were accompanied by improvement of sperm motility as well as testicular Johnsen's and Miller's criteria.

CONCLUSIONS

Since immediate testosterone treatment improved the immunoreactivity and transcription level of CADM1, the observed beneficial effect of exogenouse testosterone can be attributed to its effect on CADM1 dynamics.

摘要

目的

本研究评估了脊髓损伤（SCI）早期和慢性期外源性睾丸特异性分子1（CADM1）病理缺陷的影响。

材料与方法

在本实验研究中，在脊髓损伤诱导后立即或一周后给予睾酮。除了对CADM1基因表达及其免疫反应性进行定量外，我们还评估了脊髓损伤后的精子参数和血清睾酮水平。

结果

在急性和慢性脊髓损伤组的生精小管中，观察到精子参数和睾丸结构存在不同程度的异常，同时CADM1表达水平及其免疫反应性显著降低。外源性睾酮通过补偿血清睾酮水平，降低了附睾尾部凋亡精子以及短头和异常精子形态的百分比。重要的是，立即给予睾酮的有益效果显著。睾酮治疗的脊髓损伤小鼠睾丸中CADM1转录水平及其免疫反应性的增加伴随着精子活力以及睾丸约翰森和米勒标准的改善。

结论

由于立即给予睾酮可改善CADM1的免疫反应性和转录水平，因此观察到的外源性睾酮的有益作用可归因于其对CADM1动态变化的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db65/5893284/e145f8128c5b/Cell-J-20-138-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db65/5893284/16b2524cf5f7/Cell-J-20-138-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db65/5893284/e760e49e4c6e/Cell-J-20-138-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db65/5893284/f1f1868a25e9/Cell-J-20-138-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db65/5893284/e145f8128c5b/Cell-J-20-138-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db65/5893284/16b2524cf5f7/Cell-J-20-138-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db65/5893284/e760e49e4c6e/Cell-J-20-138-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db65/5893284/f1f1868a25e9/Cell-J-20-138-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db65/5893284/e145f8128c5b/Cell-J-20-138-g04.jpg

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