Lopes Stefanie C P, Blanco Yara C, Justo Giselle Z, Nogueira Paulo A, Rodrigues Francisco L S, Goelnitz Uta, Wunderlich Gerhard, Facchini Gustavo, Brocchi Marcelo, Duran Nelson, Costa Fabio T M
Departamento de Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, P.O. Box 6109, 13083-970 Campinas, SP, Brazil.
Antimicrob Agents Chemother. 2009 May;53(5):2149-52. doi: 10.1128/AAC.00693-08. Epub 2009 Mar 9.
Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge.
紫菌素是一种从革兰氏阴性菌紫色色杆菌中提取的紫色色素。它具有杀菌、杀肿瘤、杀锥虫和抗利什曼原虫活性。我们发现,微摩尔浓度的紫菌素在体外能有效杀死氯喹敏感和耐药的恶性疟原虫菌株;在体内即使在寄生虫已建立感染后仍能抑制虫血症;并能保护感染了恰氏疟原虫的小鼠免受致命攻击。