从紫色杆菌中提取的紫菌素在体外和体内均能抑制疟原虫的生长。
Violacein extracted from Chromobacterium violaceum inhibits Plasmodium growth in vitro and in vivo.
作者信息
Lopes Stefanie C P, Blanco Yara C, Justo Giselle Z, Nogueira Paulo A, Rodrigues Francisco L S, Goelnitz Uta, Wunderlich Gerhard, Facchini Gustavo, Brocchi Marcelo, Duran Nelson, Costa Fabio T M
机构信息
Departamento de Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, P.O. Box 6109, 13083-970 Campinas, SP, Brazil.
出版信息
Antimicrob Agents Chemother. 2009 May;53(5):2149-52. doi: 10.1128/AAC.00693-08. Epub 2009 Mar 9.
Abstract
Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge.
摘要
紫菌素是一种从革兰氏阴性菌紫色色杆菌中提取的紫色色素。它具有杀菌、杀肿瘤、杀锥虫和抗利什曼原虫活性。我们发现，微摩尔浓度的紫菌素在体外能有效杀死氯喹敏感和耐药的恶性疟原虫菌株；在体内即使在寄生虫已建立感染后仍能抑制虫血症；并能保护感染了恰氏疟原虫的小鼠免受致命攻击。
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本文引用的文献
1
Intensity of malaria transmission and the spread of Plasmodium falciparum resistant malaria: a review of epidemiologic field evidence.疟疾传播强度与恶性疟原虫耐药疟疾的传播：流行病学现场证据综述
Am J Trop Med Hyg. 2007 Dec;77(6 Suppl):170-80.
2
Violacein: properties and biological activities.紫菌素：性质与生物活性。
Biotechnol Appl Biochem. 2007 Nov;48(Pt 3):127-33. doi: 10.1042/BA20070115.
3
Cytotoxic activity of violacein in human colon cancer cells.紫罗碱对人结肠癌细胞的细胞毒性活性。
Toxicol In Vitro. 2006 Dec;20(8):1514-21. doi: 10.1016/j.tiv.2006.06.007. Epub 2006 Jul 1.
4
Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells.紫菌素协同增强5-氟尿嘧啶的细胞毒性，诱导细胞凋亡并抑制人结肠癌细胞中Akt介导的信号转导。
Carcinogenesis. 2006 Mar;27(3):508-16. doi: 10.1093/carcin/bgi307. Epub 2005 Dec 12.
5
The Plasmodium sporozoite survives RTS,S vaccination.疟原虫子孢子能在RTS,S疫苗接种后存活。
Trends Parasitol. 2005 Oct;21(10):456-61. doi: 10.1016/j.pt.2005.08.002.
6
Molecular mechanism of violacein-mediated human leukemia cell death.紫罗碱介导人白血病细胞死亡的分子机制。
Blood. 2004 Sep 1;104(5):1459-64. doi: 10.1182/blood-2004-02-0594. Epub 2004 May 6.
7
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Toxicology. 2003 Apr 22;186(3):217-25. doi: 10.1016/s0300-483x(02)00751-5.
8
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J Antimicrob Chemother. 2001 Sep;48(3):449-50. doi: 10.1093/jac/48.3.449.
10
Violacein cytotoxicity and induction of apoptosis in V79 cells.紫菌素对V79细胞的细胞毒性及凋亡诱导作用。
In Vitro Cell Dev Biol Anim. 2000 Sep;36(8):539-43. doi: 10.1290/1071-2690(2000)036<0539:vcaioa>2.0.co;2.
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