Nakayama M, Miura H, Kamei T
Department of Internal Medicine, Yokosuka Kyosai Hospital, Japan.
Acta Otolaryngol Suppl. 1991;481:481-5. doi: 10.3109/00016489109131452.
Vestibular function testing was performed regularly on patients who were administered streptomycin, kanamycin, or enviomycin, and vestibular damage was detected at an early stage, and quantitatively. We investigated the point in time at which the therapy should be discontinued. Subjects consisted of 204 cases of tuberculosis treated with streptomycin, kanamycin, enviomycin. They were admitted to the hospital between December 1984 and August 1989. Twenty-eight cases of vestibular dysfunction due to streptomycin, kanamycin, and enviomycin could easily be detected at an early stage by performing Meyer zum Gottesberge's head-shaking test for the evaluation of jumbling, together with Romberg's test and the stepping test. All cases who had vestibular dysfunction completely recovered because of early detection. In addition, 7 cases recovered afterwards from temporary vestibular damage shown only in Meyer zum Gottesberge's head-shaking test (abnormality of vestibulo-ocular reflex was only detected and vestibulo-spinal reflex remained intact), despite continuation of streptomycin injection. When the results of the head-shaking test are less than 50% and when a sway and/or rotation in the stepping test occurs, the injections should be discontinued.
对接受链霉素、卡那霉素或恩维霉素治疗的患者定期进行前庭功能测试，可在早期定量检测到前庭损伤。我们研究了应停止治疗的时间点。研究对象包括204例接受链霉素、卡那霉素、恩维霉素治疗的结核病患者。他们于1984年12月至1989年8月期间入院。通过进行迈耶·祖姆·戈特斯贝格摇头试验（用于评估眩晕）、罗姆伯格试验和踏步试验，可在早期轻松检测出28例由链霉素、卡那霉素和恩维霉素引起的前庭功能障碍。所有出现前庭功能障碍的病例均因早期检测而完全康复。此外，7例患者在仅迈耶·祖姆·戈特斯贝格摇头试验显示有暂时性前庭损伤（仅检测到前庭眼反射异常，前庭脊髓反射保持完整）的情况下，尽管继续注射链霉素，后来仍康复。当摇头试验结果低于50%，且踏步试验出现摇摆和/或旋转时，应停止注射。
